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Study identifies two genes that play key role in protecting ovarian cancer from the immune system

Immunotherapies have shown striking clinical benefit in the treatment of many cancers, especially when used in combination with chemotherapy. ....

United States , Jianhuang Lin , Rugang Zhang , Christopherm Davis , Emily Henderson , Cancer Immunology Research , American Association For Cancer Research , Cancer Center , Zhang Laboratory , Microenvironment Metastasis Program , Wistar Institute , American Association , Cancer Research , Endowed Professor , Metastasis Program , Immune System , Ovarian Cancer ,

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas
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United States , Rugang Zhang , Joseph Zundell , Emily Henderson , Cancer Research , American Association For Cancer Research , Cancer Center , Microenvironment Metastasis Program , Wistar Institute , American Association , Study Lead Author , Deputy Director , Metastasis Program , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் மையம் , அமெரிக்கன் சங்கம் , படிப்பு வழி நடத்து நூலாசிரியர் , துணை இயக்குனர் ,

New mechanism by which senescent cells turn on genes encoding for tumor-regulating factors

Credit: The Wistar Institute
PHILADELPHIA (April 1, 2021 Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment. The study, published in
Nature Cell Biology, reports that methyltransferase-like 3 (METTL3) and 14 (METTL14) proteins moonlight as transcriptional regulators that allow for establishment of the senescence-associated secretory phenotype (SASP).
Cellular senescence is a stable state of growth arrest in which cells stop dividing but remain viable and produce an array of inflammatory and growth-promoting molecules collectively defined as SASP. These molecules account for the complex crosstalk between senescent cells and neighboring cells and the effect of cellular senescence in various physiological processes and diseases. Although senescence is regarded as a potent bar ....

United States , Andrewv Kossenkov , Rugang Zhang , Timothy Nacarelli , Xue Hao , Jianhuang Lin , Pingyu Liu , Christopherm Davis , Takeshi Fukumoto , M Celeste Simon , Us Department Of Defense , National Cancer Institute , National Institutes Of Health , Zhang Lab , Cancer Center , University Of Pennsylvania , Tina Brozman Ovarian Cancer Research Consortium , Wistar Institute , Microenvironment Metastasis Program , Wistar Institute Cancer Center , Cancer Center Support Grant , Nature Cell Biology , National Institutes , Honorable Tina Brozman Foundation , Ovarian Cancer Research , Ovarian Cancer Research Alliance ,

Jubilant Therapeutics Announces Research Collaboration with The Wistar Institute to Evaluate the Activity of Novel PAD4 Inhibitors to Reduce Clinical Severity of COVID-19

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BEDMINSTER, N.J., Jan. 15, 2021 /PRNewswire/ Jubilant Therapeutics Inc., a biopharmaceutical company advancing small molecule modulators to address unmet medical needs in oncology and autoimmune diseases, today announced a collaboration with The Wistar Institute, an international leader in biomedical research, to evaluate the ability of Peptidyl Arginine Deiminase 4 (PAD4) inhibitors provided by Jubilant Therapeutics to block neutrophil extracellular trap (NET) formation in the context of COVID-19 related cytokine storms.
PAD4 is an enzyme that catalyzes conversion of arginine to citrulline in proteins, including histones and is highly expressed in neutrophils. Histone citrullination has been implicated in Neutrophil Extracellular Trap (NET) formation and accumulating evidence suggests that NETs may be linked to the severity of COVID-19, as their formation is a result of pro-inflammatory cytokine release syndrome (CRS), or cytokine storms, produced by the body s im ....

United States , Kostenloser Wertpapierhandel , Syed Kazmi , Yulia Nefedova , National Cancer Institute , Cancer Center , Jubilant Therapeutics Inc , Jubilant Life Sciences , Prnewswire Jubilant Therapeutics Inc , Wistar Institute , Microenvironment Metastasis Program , Therapeutics Inc , Peptidyl Arginine , Jubilant Therapeutics , Neutrophil Extracellular Trap , Chief Executive Officer , Metastasis Program , Jubilant Therapeutic , Jubilant Life Sciences Limited , Co Vid , ஒன்றுபட்டது மாநிலங்களில் , சையத் காஜ்மி , தேசிய புற்றுநோய் நிறுவனம் , புற்றுநோய் மையம் , மகிழ்ச்சி சிகிச்சை இன்க் , மகிழ்ச்சி வாழ்க்கை அறிவியல் ,

Researchers Identify Link Between Ovarian Cancer, Metabolism

Researchers Identify Link Between Ovarian Cancer, Metabolism
by Angela Mohan on
January 12, 2021 at 5:24 PM
Nature Cancer.
Up to 60% of ovarian clear cell carcinomas (OCCC) have inactivating mutations in the ARID1A tumor suppressor gene. These mutations are known genetic drivers of this type of cancer, which typically does not respond to chemotherapy and carries the worst prognosis among all subtypes of ovarian cancer.
The laboratory of Rugang Zhang, Ph.D., deputy director of The Wistar Institute Cancer Center, professor and leader of the Immunology, Microenvironment & Metastasis Program, studies the effects of ARID1A inactivation to devise new mechanism-guided therapeutic strategies and combination approaches to enhance immunotherapy for ovarian cancer. ....

Rugang Zhang , Shuai Wu , Zhang Lab , Microenvironment Metastasis Program , Wistar Institute , Wistar Institute Cancer Center , Metastasis Program , Metabolism For Weight , Ovarian Cancer , Glutamine Metabolism , Arid1a Mutant , Clear Cell Carcinoma , Therapeutic Strategies , ஷுை வு , ஜாங் ஆய்வகம் , வளர்சிதை மாற்றம் க்கு எடை , ஓவாயரியந் புற்றுநோய் , தெளிவானது செல் புற்றுநோய் , சிகிச்சை உத்திகள் ,