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UC San Diego researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little.

Scientists at St. Jude Children's Research Hospital have shown how a protein responsible for adapting to low oxygen conditions (hypoxia), causes increased expression of fetal hemoglobin (HbF) in adults.

Four Penn faculty elected to the National Academy of Sciences The new members of the Academy, honored scholars recognized for their unique and ongoing contributions to original research, include researchers from the Perelman School of Medicine, School of Engineering and Applied Science, and Annenberg School for Communication. As newly elected members of the U.S. National Academy of Sciences, (clockwise from top left) Marisa Bartolomei and M. Celeste Simon from the Perelman School of Medicine, Michael Kearns from the School of Engineering and Appli...

Credit: The Wistar Institute PHILADELPHIA -- (April 1, 2021 -- Scientists at The Wistar Institute identified a new mechanism of transcriptional control of cellular senescence that drives the release of inflammatory molecules that influence tumor development through altering the surrounding microenvironment. The study, published in Nature Cell Biology, reports that methyltransferase-like 3 (METTL3) and 14 (METTL14) proteins moonlight as transcriptional regulators that allow for establishment of the senescence-associated secretory phenotype (SASP). Cellular senescence is a stable state of gro...