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Base editing shows potential superiority for

Adenosine base editing restarted fetal hemoglobin expression in cells from patients with sickle cell disease. Find how St. Jude & Broad are advancing to a cure. ....

United States , Yong Cheng , Yoonjeong Jang , Jingjing Chen , Yu Yao , Rachel Levine , Senthil Velan Bhoopalan , Ruopeng Feng , Mitchell Weiss , David Liu , John Tisdale , Yichao Li , Shondra Pruett Miller , Akshay Sharma , Henry Bell , Thiyagaraj Mayuranathan , Gregory Newby , Richard Merkin , Shengdar Tsai , Shaina Porter , Erin Dempsey , Nikitha Nimmagadda , Kalin Mayberry , Merlin Crossley , Guolian Kang , Cicera Lazzarotto ,

Base editing shows promise for treating sickle cell disease and beta thalassemia

Gene therapy that alters hemoglobin genes may be an answer to curing sickle cell disease (SCD) and beta thalassemia. ....

United States , Lily Ramsey , Senthil Velan Bhoopalan , Cicera Lazzarotto , Guolian Kang , Yong Cheng , Phillip Doerfler , Erin Dempsey , Mitchell Weiss , Gregory Newby , Ruopeng Feng , Yu Yao , Rachel Levine , Jingjing Zhang , Shengdar Tsai , Henry Bell , Yoonjeong Jang , Jingjing Chen , Richard Merkin , Kalin Mayberry , Merlin Crossley , David Liu , Thiyagaraj Mayuranathan , John Tisdale , Yichao Li , Shaina Porter ,

Research Roundup: Findings in Sickle Cell Disease, Alzheimer's, Allergic Asthma and More

This week, new research is presented in treatments for sickle cell disease, Alzheimer's, asthma, and type 1 diabetes. Here's a look at that and more. ....

Ruopeng Feng , Stefan Feske , Langone Health , Grossman School Of Medicine , Research Gettystock , Jude Children Research Hospital , Department Of Pathology , Sickle Cell , Jude Children , Research Hospital , Nerve Growth Factor , Allergic Asthma , Weakening Defenses , Jeffrey Bergstein Professor , Esearch Roundup Findings In Sickle Cell Disease , Alzheimer 39 S , Llergic Asthma And More ,

A link between hypoxia and fetal hemoglobin provides hope for sickle cell disease

Cellular response to low oxygen also increases fetal hemoglobin expression in adults, which could lead to novel treatments for some genetic anemias. ....

Mitchellj Weiss , Ruopeng Feng , Jude Children Research Hospital , Jude Hematology Department , Jude Children , Research Hospital , Sickle Cell , Fetal Hemoglobin ,

Link between hypoxia and fetal hemoglobin provides hope for sickle cell disease

Link between hypoxia and fetal hemoglobin provides hope for sickle cell disease
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United States , University Of Pennsylvania , Peng Xu , Yong Cheng , Lance Palmer , Peng Huang , Kalin Mayberry , Ruopeng Feng , Mitchellj Weiss , Thiyagaraj Mayuranathan , M Celeste Simon , Chunliang Li , Gerda Blobel , Phillipa Doerfler , Yu Yao , Jingjing Zhang , Yichao Li , Georgios Christakopoulos , National Institute Of Diabetes , Jude Children Research Hospital , National Institutes Of Health , Jude Hematology Department , Jude Collaborative Research Consortium , Cooley Anemia Foundation Postdoctoral Research Award , Assisi Foundation Of Memphis , Jude Hematology ,