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Study may lead to new therapeutic strategies to reduce allergic responses, inflammatory reactions


Study may lead to new therapeutic strategies to reduce allergic responses, inflammatory reactions
In order to fight pathogens, mast cells regulate inflammatory reactions of the immune system. Both mast cells and neutrophils are white blood cells and are critical for the body s immune defense. A team of scientists around the immunologist Prof. Dr. Anne Dudeck and the bioengineer Jan Dudeck has discovered a crucial aspect of the communication between mast cells and neutrophils.
These new findings may allow for developing innovative, targeted therapeutic strategies to dampen allergic responses and inflammatory reactions. The results have been published in the renowned journal ....

Anne Dudeck , Jan Dudeck , Emily Henderson , University Magdeburg , Institute For Molecular , Clinical Immunology , Otto Von Guericke University , Blood Vessel , Immune Response , Immune System , Mast Cell , எமிலி ஹென்டர்சன் , நிறுவனம் க்கு மூலக்கூறு , மருத்துவ நோயெதிர்ப்பு , இரத்தம் கப்பல் , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு , மாஸ்ட் செல் ,

CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases


CoCID project aims to develop soft X-ray microscope for visualizing cellular origin of diseases
CoCID (Compact Cell Imaging Device), a €5.7 million, four-year, pan-European research and innovation project, funded through Horizon 2020, has officially commenced. CoCID is focused on the development of a soft X-ray-based methodology that enables fast and inexpensive three-dimensional imaging of whole internal structure of intact biological cells.
The objective of CoCID is to develop a lab-scale, soft X-ray microscope, which can be used as a research tool to help scientists to understand the cellular origin of diseases.
The benefits of this compact imaging device will be demonstrated through a series of virology use cases that enable researchers to decipher critical changes in cell morphology induced by viruses, such as SARS-CoV-2, in their host cell with the aim to identify possible targets for therapy suppressing virus replication and/or cellular responses of relevance ....

Baden Wuberg , Eva Pereiro , Tony Mcenroe , Maija Vihinen Ranta , Emily Henderson , Nicola Fletcher , Ralf Bartenschlager , Pablo Gastaminza , Venera Weinhardt , Centre For Organismal , School Of Veterinary Medicine , University College Dublin , Heidelberg University Hospital , National Centre For Biotechnology , University Of Jyv , Department Of Molecular , University Of Heidelberg , Spanish National Research Council , Compact Cell Imaging Device , Ruprecht Karls University Heidelberg , National Centre , Alba Synchrotron , Assistant Professor Nicola Fletcher , Molecular Virologist , Principal Investigator , Cellular Biology ,

Innovative breakthrough promises to diagnose DNA rearrangement mutations


Innovative breakthrough promises to diagnose DNA rearrangement mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.
However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in the lengths of genes in a DNA sequence. These variations in gene length, known as polymorphisms, can be key to accurately diagnosing many forms of c ....

United States , Alden Chesney , Jason Reed , Amir Toor , Emily Henderson , School Of Medicine , College Of Humanities , Virginia Commonwealth University Massey Cancer Center , American Society Of Hematology , Department Of Pathology , Association Of Molecular Pathology , Professor In Department Of Physics , Department Of Physics , Member Of Cancer Biology Research Program , Massey Cancer Center , Molecular Pathology , American Society , Cancer Center , Cancer Biology Research Program , Associate Professor , Virginia Commonwealth , Developmental Therapeutics , Dna Sequencing , Atomic Force Microscopy , Polymerase Chain Reaction , ஒன்றுபட்டது மாநிலங்களில் ,