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Closer to cure: New imaging method tracks cancer treatment efficacy in preclinical studies

The National Institutes for Quantum and Radiological Science and Technology
Several cancer tumors grow through immunosuppression; that is, they manipulate biological systems in their microenvironments and signal to a specific set of immune cells–those that clear out aberrant cells–to stop acting. It is no wonder that immunotherapy designed to re-establish anti-tumor immunity is rapidly becoming the treatment of choice for these cancers.
One natural immunosuppressive molecule that falls prey to helping cancer tumors is indoleamine-2,3-dioxygenase 1 (henceforth, IDO1). Because it is found in a broad range of cancer tumors, including those of the skin, breast, colon, lung, and blood, scientists have begun to see it as a promising therapeutic target: Suppress its activity and anti-tumor immunity should be back. But all endeavors so far have failed in phase 3 clinical trials–the stage at which a large number of people with the disease try out the optimal dose to test its ....

Ming Rong Zhang , Lin Xie , National Institutes For Quantum , Department Of Advanced Nuclear Medicine Sciences , Advanced Nuclear Medicine Sciences , National Institutes , Radiological Science , லின் க்ஷிஎ , தேசிய நிறுவனங்கள் க்கு குவாண்டம் , தேசிய நிறுவனங்கள் , கதிரியக்கவியல் அறிவியல் ,

New PET imaging method tracks immunotherapeutic efficacy in mouse models

New PET imaging method tracks immunotherapeutic efficacy in mouse models
Several cancer tumors grow through immunosuppression; that is, they manipulate biological systems in their microenvironments and signal to a specific set of immune cells those that clear out aberrant cells to stop acting. It is no wonder that immunotherapy designed to re-establish anti-tumor immunity is rapidly becoming the treatment of choice for these cancers.
One natural immunosuppressive molecule that falls prey to helping cancer tumors is indoleamine-2,3-dioxygenase 1 (henceforth, IDO1).
Because it is found in a broad range of cancer tumors, including those of the skin, breast, colon, lung, and blood, scientists have begun to see it as a promising therapeutic target: Suppress its activity and anti-tumor immunity should be back. But all endeavors so far have failed in phase 3 clinical trials the stage at which a large number of people with the disease try out the optimal dose to test its true ....

Ming Rong Zhang , Lin Xie , Emily Henderson , National Institutes For Quantum , Department Of Advanced Nuclear Medicine Sciences , Advanced Nuclear Medicine Sciences , National Institutes , Radiological Science , லின் க்ஷிஎ , எமிலி ஹென்டர்சன் , தேசிய நிறுவனங்கள் க்கு குவாண்டம் , தேசிய நிறுவனங்கள் , கதிரியக்கவியல் அறிவியல் ,

NIMH » Trainee Successes: Past & Present

Shahriar SheikhBahaei, Ph.D.
Dr. SheikhBahaei’s interest in neuroscience stemmed from the usual combination of an aptitude for science and a medical problem (stuttering) that brought him into bioscience at a young age. Dr. SheikhBahaei received his bachelor’s degree from the University of California at Berkeley, where he worked with Dr. Bob Zucker on the regulation of neurotransmitter release and Dr. John Rubenstein (UC San Francisco) on development of GABAergic neurons in basal ganglia. Dr. SheikhBahaei completed his doctoral studies in Neuroscience (2017) jointly under NIMH/NINDS – University College London (UCL) Graduate Partnership Program where he worked with Drs. Jeffrey Smith (NINDS) and Alexander Gourine (UCL). His graduate studies were on how astrocytic networks control activities of respiratory motor circuits within the brainstem. After short postdoctoral research at NINDS, Dr. SheikhBahaei became an Independent Research Scholar in 2019. In collaboration with t ....

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