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Variations in mitochondrial function and NGF levels between children with autism spectrum disorder and healthy controls.

 E-Mail Newly published papers further elucidate the mechanisms underlying pridopidine's neuroprotective properties through activation of the Sigma-1 Receptor (S1R). Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R. Three new peer-reviewed publications highlight pridopidine's therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative...

Swiss life sciences company Amazentis has combined Mitopure (urolithin A) with high protein to increase sports performance, recovery, and overall cellular health.

Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH. Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O 2) exposure for 3 weeks. FDCA (15, 45, or 135 mg/kg i.g. daily) or the positive control, bosentan (100 mg/kg i.g....