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New research supports pridopidine's neuroprotective properties in Huntington's Disease models

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Newly published papers further elucidate the mechanisms underlying pridopidine s neuroprotective properties through activation of the Sigma-1 Receptor (S1R).
Pridopidine enhances mitochondrial function and reduces mHTT-induced ER stress, which are impaired in HD, mediated by the S1R.
Three new peer-reviewed publications highlight pridopidine s therapeutic potential and provide data supporting the role of the S1R in neurodegenerative diseases
Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases. ....

Michaelr Hayden , Huntington Study Group , Healey Center , International Journal Of Molecular Sciences , Mediates Pridopidine Rescue , Mitochondrial Function , Huntington Disease Models , Its Role , Neurodegenerative Diseases , International Journal , Molecular Sciences , Amyotrophic Lateral Sclerosis , Global Phase , Total Functional Capacity , Mass General , Health Care , Pharmaceutical Sciences , Medicine Health , Clinical Trials , Health Professionals , ஹண்டிங்டன் படிப்பு குழு , ஹீலி மையம் , சர்வதேச இதழ் ஆஃப் மூலக்கூறு அறிவியல் , மைட்டோகாண்ட்ரியல் செயல்பாடு , அதன் பங்கு , சர்வதேச இதழ் ,

FDCA ameliorates SU5416/hypoxia-induced PASMC dysfunction

Background: Pulmonary arterial hypertension (PAH) is an incurable disease that urgently needs therapeutic approaches. Based on the therapeutic effects of fasudil and dichloroacetate (DCA) on PAH, we aimed to explore the effects and potential mechanism of a new salt, fasudil dichloroacetate (FDCA), in a SU5416 plus hypoxia (SuHx)-induced rat model of PAH.
Methods: The rat model of PAH was established by a single subcutaneous injection of SU5416 (20 mg/kg) followed by hypoxia (10% O
2) exposure for 3 weeks. FDCA (15, 45, or 135 mg/kg i.g. daily) or the positive control, bosentan (100 mg/kg i.g. daily), were administered from the first day after SU5416 injection. After 3-week hypoxia, hemodynamic parameters, and histological changes of the pulmonary arterial vessels and right ventricle (RV) were assessed. Additionally, in vitro, the effects of FDCA (50 μM), compared with equimolar doses of fasudil, DCA, or fasudil+DCA, on the proliferation, migration, and contraction of huma ....

United States , San Diego , United Kingdom , Pasmcs Sciencell , Laboratory Animals , Chemical Technology Co Ltd , Image Lab , Aipu Instrument Equipment Co Ltd , Proteintech Group , China Pharmaceutical University , Committee Of Nanjing Medical University , Bikai Laboratory Animal Company , Cell Signaling Technology , Key Laboratory Of Natural Medicine , Huaxi Electronic Technology Co Ltd , Power Lab , National Institutes , Health Guidelines , Institutional Animal Care , Use Committee , Nanjing Medical University , State Key Laboratory , Natural Medicine , Right Heart Hypertrophy , Thermo Scientific , Corning Costar ,