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An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice

An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

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Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Genecust Boynes , Swedish Research Council , Protein Data Bank , Ss Sidhu University Of Toronto , Swedish Foundation For Strategic Research , Protein Data , Eukaryotic Linear Motif , Human Protein Atlas , Free Protein Gels , Mode Microplate Reader , Molecular Devices , Swedish Foundation , Strategic Research ,

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United States , Lisa Wagar , Takara Bio , Masaru Kanekiyo , Miltenyi Biotec , Elizabeth Mellins , Naresha Saligrama , Alexandra Skye Lee , Mark Davis , Yamuna Kalyani Mathiharan , Roshni Roy Chowdhury , Trustain Fcx Biolegend , Yueh Hsiu Chien , Seann Parker , Melinda Gates Foundation , Stanford Occupational Health , Seann Parker Center , Fortebio Data Analysis Software , Sunshine Foundation , Howard Hughes Medical Institute , New England Biolabs , Elim Biopharm , Thermo Fisher Scientific , Mode Microplate Reader , Molecular Devices , Bestbac Linearized Baculovirus ,

[Full text] Resiquimod for Prostate Cancer Treatment

Purpose: With the advance of screening techniques, there is a growing number of low-risk or intermediate-risk prostate cancer (PCa) cases, remaining a serious threat to men’s health. To obtain better efficacy, a growing interest has been attracted to develop such emerging treatments as immunotherapy and focal therapy. However, few studies offer guidance on whether and how to combine these modalities against PCa. This study was designed to develop dual-functional nanoparticles (NPs) which combined photothermal therapy (PTT) with immunotherapy and determine the anti-tumor efficacy for PCa treatment.
Methods: By a double emulsion technique, the drug nanocarrier, poly(lactic-co-glycolic acid) or PLGA, was applied for co-loading of a fluorescent dye, indocyanine green (ICG) and a toll-like receptor 7/8 (TLR7/8) agonist resiquimod (R848) to synthesize PLGA-ICG-R848 NPs. Next, we determined their characteristic features and evaluated whether they inhibited the cell viability in mul ....

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