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Selective CDK2 Inhibitor Undergoes Investigation in CCNE1-High Tumors

Preclinical data have demonstrated activity of a novel, small molecule CDK2 inhibitor INCB123667 in CDK2/cyclin E1 expressing cell lines prompting investigators to initiate a phase 1 study, and the agent may fill an unmet need for patients with cancers with primary or acquired CDK4/6 resistance. ....

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Established therapy could bring new hope to patients with triple negative breast cancer

Established therapy could bring new hope to patients with triple negative breast cancer
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Potential of Precision Genomics Established in Cancer Treatment

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Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analysed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques.
Carried out by Lydia King during her studies in NUI Galwayâs MSc in Biomedical Genomics programme, the research has been published in the international journal PLOS ONE.
Early detection by national screening programmes and timely treatment for patients diagnosed with âluminalâ types of breast cancer have resulted in excellent prognoses with survival rates of over 80% within five years of treatment. The challenge of long-term survival however is not as well understood and studies have shown that more than half of all recurrences for luminal breast cancers takes place after this time point. Identifying patients most likely to suffe ....

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Scientists identify genomic signatures of long-term survival in luminal breast cancer patients

Scientists identify genomic signatures of long-term survival in luminal breast cancer patients
Researchers at NUI Galway have identified genomic signatures in women developing the most common type of breast cancer that can be associated with long-term survival. The NUI Galway team analyzed the genomes of breast cancer patients to look for associations with survival rates using advanced statistical techniques.
Carried out by Lydia King during her studies in NUI Galway s MSc in Biomedical Genomics programme, the research has been published in the international journal
PLOS ONE.
Early detection by national screening programmes and timely treatment for patients diagnosed with luminal types of breast cancer have resulted in excellent prognoses with survival rates of over 80% within five years of treatment. The challenge of long-term survival however is not as well understood and studies have shown that more than half of all recurrences for luminal breast cancers take ....

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