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Impact and cost-effectiveness of the 6-month BPaLM regimen for rifampicin-resistant tuberculosis in Moldova: A mathematical modeling analysis

Author summary Why was this study done? Drug resistance poses a major barrier to the effective treatment of tuberculosis, especially in Moldova and other post-Soviet states which have the highest levels of resistance in the world. Individuals with tuberculosis resistant to the key drug rifampicin face a worse prognosis, a longer and more expensive course of treatment, and more side effects than individuals with rifampicin-susceptible tuberculosis. Until recently, the standard of care for rifampicin-resistant tuberculosis (RR-TB) involved many drugs in combination, often given for 18 months or longer. The newer, 6-month “BPaLM” regimen is comprised of 4 drugs (bedaquiline, pretomanid, linezolid, and moxifloxacin) to which resistance levels are currently low, and while it was shown to be just as effective as the standard of care when health outcomes were measured at 72 weeks from treatment initiation, its effect on lifetime health outcomes, costs, and the acquisition of dru ....

United States , United Kingdom , South Africa , Jennifer Thorley , National Institute Of Allergy , Decision Science Methods Group At Erasmus University , Harvard University , Tb Partnership Global Drug Facility , Health Decision Science , Phd Program In Health , Creative Commons Attribution License , National Institute , Infectious Diseases , Global Drug Facility , Consumer Price Index , Moldovan Leu , Gross Domestic Product , Georgian Lei , Soviet Union , Like Moldova , Although South Africa , Phd Program , Health Policy , Decision Science Methods Group , Erasmus University , Drug Therapy ,

Destiny 2: Xur Exotic Armor, Weapon, and Recommendations for January 5

Destiny 2: Xur Exotic Armor, Weapon, and Recommendations for January 5
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Destiny 2 update 7.3.0.1 patch notes

The patch notes for Destiny 2 update 7.3.0.1 fix some issues in Crota s End, Riven s Lair, and more. ....

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Destiny 2 Update 7.3.0.1 Brings Fixes for Crucible, Raids and More

Destiny 2 Update 7.3.0.1 Brings Fixes for Crucible, Raids and More
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"Dependence of Induced Biological Damage on the Energy Distribution and" by Rafael Colmenares, Rebeca Carrión-Marchante et al.

The survival fraction of epithelial HaCaT cells was analysed to assess the biological damage caused by intraoperative radiotherapy electron beams with varying energy spectra and intensities. These conditions were achieved by irradiating the cells at different depths in water using nominal 6 MeV electron beams while consistently delivering a dose of 5 Gy to the cell layer. Furthermore, a Monte Carlo simulation of the entire irradiation procedure was performed to evaluate the molecular damage in terms of molecular dissociations induced by the radiation. A significant agreement was found between the molecular damage predicted by the simulation and the damage derived from the analysis of the survival fraction. In both cases, a linear relationship was evident, indicating a clear tendency for increased damage as the averaged incident electron energy and intensity decreased for a constant absorbed dose, lowering the dose rate. This trend suggests that the radiation may have a more pronounced ....

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