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"A Monte Carlo study to evaluate and optimise the angular dependence of" by Ilia Filipev, Giordano Biasi et al.

Purpose: A detector assembly based on a 2D silicon array sensor, Octa, was previously demonstrated to be accurate for small field relative dosimetry. Experimental studies showed angular dependence of the response that has also variations with the field size. A Monte Carlo simulation model was developed and used in this work to study how the detector assembly's components contribute to the observed angular dependence. Methods: Geant4 was used as the Monte Carlo code. A detailed model of the Octa detector and its packaging was placed in the centre of a solid water phantom with the central sensitive volumes (SVs) located at the isocentre and irradiated at polar angles from 0 to 180° (the beam was normal to the detector plane at 0°). Phase-space files from the IAEA database were used to model a CyberKnife X-ray beam with collimator diameters of 5, 10, and 15 mm. Reference simulations were compared with previous experimental results. To investigate the impact of the assembly's m ....

Monte Carlo , Cyberknifex Ray , 2d Monolithic Silicon Array Detector , Angular Dependence , Monte Carlo Simulation , Mall field Dosimetry , Stereotactic Ablative Body Radiotherapy ,

"In-silico calculations of DNA damage induced by &#x3B1;-particles in the <su" by Laura Ballisat, Lana Beck et al.

Diffusing alpha-emitters radiation Therapy (DaRT) is an interstitial brachytherapy technique using 224Ra seeds. For accurate treatment planning a good understanding of the early DNA damage due to α-particles is required. Geant4-DNA was used to calculate the initial DNA damage and radiobiological effectiveness due to α-particles with linear energy transfer (LET) values in the range 57.5–225.9 keV/μm from the 224Ra decay chain. The impact of DNA base pair density on DNA damage has been modelled, as this parameter varies between human cell lines. Results show that the quantity and complexity of DNA damage changes with LET as expected. Indirect damage, due to water radical reactions with the DNA, decreases and becomes less significant at higher LET values as shown in previous studies. As expected, the yield of complex double strand breaks (DSBs), which are harder for a cell to repair, increases approximately linearly with LET. The level of complexity of DSBs and radiobiological effect ....

Dna Damage , Eant4 Dna , Monte Carlo Simulation ,