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15 March 2021 In this application note, The Jackson Laboratory demonstrate how the cord blood CD34+ hematopoietic stem cell (HSC) humanized NSG™-IL15 mouse enables in vivo efficacy research for compounds targeting human natural killer (NK) cell activity including antibody-dependent cellular cytotoxicity (ADCC). Download 10,000+
New tumor-penetrating therapy may improve outcomes in patients with pancreatic cancer Every 12 minutes, someone in the United States dies of pancreatic cancer, which is often diagnosed late, spreads rapidly and has a five-year survival rate at approximately 10 percent. Treatment may involve radiation, surgery and chemotherapy, though often the cancer becomes resistant to drugs. Researchers at University of California San Diego School of Medicine and Moores Cancer Center, in collaboration with Sanford-Burnham-Prebys Medical Discovery Institute and Columbia University, demonstrated that a new t...
CBD ameliorates cognitive function in experimental model of familial Alzheimer's A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer's disease, and improves cognition in an experimental model of early onset familial Alzheimer's, investigators report. The proteins TREM2 and IL-33 are important to the ability of the brain's immune cells to literally consume dead cells and other debris like the beta-amyloid plaque that piles up in patients' brains, and levels of both are decreased in Al...
Researchers find new way to prevent attention deficits associated with Fragile X syndrome Mount Sinai Researchers find a new way to prevent attention deficits associated with Fragile X, a leading genetic cause of autism, in an animal model. Corresponding author: Hirofumi Morishita, MD, Ph.D., Department of Psychiatry, Neuroscience, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York. Bottom line: The adolescent maturation of the frontal cortex is important for establishing cognitive function, and disruption of this proces...
A new study reports positive outcomes from two new vaccine candidates. The research, led by Axel T. Lehrer from the University of Hawaii at Manoa, studied mice's immune response when administered the CoVaccine HT adjuvant with an insect-cell expressed SARS-CoV-2 spike protein ectodomain.