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Zanubrutinib Triplet Shows Early Promise in Treatment-Naive TP53-Mutant MCL

The combination comprised of zanubrutinib, obinutuzumab, and venetoclax elicited high response rates and 2-year progression-free survival rates that compared favorably with historical outcomes achieved with chemoimmunotherapy in high-risk patients with previously untreated mantle cell lymphoma harboring TP53 mutations. ....

Anita Kumar , Memorial Sloan Kettering Cancer Center , Department Of Medicine , Multicenter Phase , Mutant Mantle Cell , Untreated Mantle Cell ,