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Best Approaches to Switching Therapies for a Patient With Myelofibrosis

Reasons to switch JAK inhibitors include worsening blood counts and insufficient symptom or spleen response at maximum doses, with the goal of avoiding gaps in treatment by stopping one JAK inhibitor when ready to start the next to prevent symptom rebound while still allowing for potential increased efficacy from an alternative mechanism of action. ....

Myelofibrosis Treatment , Enhancing Patient Quality , Switching Therapies , Patient With ,

Dr Tantravahi on the Efficacy of Selinexor Plus Ruxolitinib in JAK Inhibitor–Naive Myelofibrosis

Srinivas K. Tantravahi, MBBS, MRCP, discusses the preliminary efficacy of selinexor in combination with ruxolitinib in patients with JAK inhibitor–naive myelofibrosis, as seen in the phase 1 XPORT-MF-034 trial. ....

United States , Srinivask Tantravahi , University Of Utah Huntsman Cancer Institute , Utah Huntsman Cancer Institute , Reviewing Research Efforts Seeking To Raise The Bar In Myelofibrosis , Onclive Tv , Phase 1 3 Xport Mf 034 Trial , Jak Inhibitor Naive ,

Inpatient to Outpatient: Myelofibrosis Care

Pharmacists discuss challenges in transitioning myelofibrosis patients between inpatient and outpatient care settings, emphasizing medication reconciliation and seamless inter-team communication. ....

Treatment Landscape , Pharmacists X27 Role , Clinical Practice , Emerging Therapies , Phase Three Trial , Nccn Guidelines , Transfusion Dependence , Spleen Volume Reduction ,

Emerging Therapies and Momelotinib Impact

James Davis, PharmD, BCOP, discusses momelotinib usage and highlights emerging therapies revolutionizing myelofibrosis treatment paradigms. ....

James Davis , Emerging Therapies , Treatment Landscape , Pharmacists X27 Role , Clinical Practice , Phase Three Trial , Nccn Guidelines , Transfusion Dependence , Spleen Volume Reduction ,

Adverse Events Seen With JAK Inhibitors for Myelofibrosis

The JAK inhibitors approved for myelofibrosis have common side effects of cytopenias and gastrointestinal issues, with additional risks of weight gain and cardiac effects and diarrhea; momelotinib and pacritinib show improved tolerability compared to earlier JAK inhibitors. ....

Myelofibrosis Treatment , Enhancing Patient Quality ,