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Pelabresib/Ruxolitinib Combo Improves Splenomegaly, TSS in JAK Inhibitor–Naive Myelofibrosis

Pelabresib plus ruxolitinib demonstrated a 35% or greater reduction in spleen volume and trended toward reducing mean absolute total symptom score (TSS) as well as improving TSS reduction by 50% at 24 weeks in patients with JAK inhibitor–naive myelofibrosis. ....

Zentalis Incyte , Ryvu Incyte , Biopharm Corp , Pharm Corp , Palebresib Plus Ruxolitinib , Jak Inhibitor Naive Myelofibrosis , Manifest 2 Trial , Ash Annual Meeting , Cpi 0610 ,

New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens – a major indicator of clinical improvement – compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center. ....

United States , Naveen Pemmaraju , American Society Of Hematology , University Of Texas Md Anderson Cancer Center , Manderson Cancer , Annual Meeting , Drug Administration Approved , Bone Marrow , Clinical Trial , Jak Inhibitor ,

Dr Andrew Srisuwananukorn on the Potential for AI in Differentiating prePMF and ET

Andrew Srisuwananukorn, MD, of the Ohio State University Comprehensive Cancer Center, explained the potential of artificial intelligence (AI)-based support tools for differentiating primary myelofibrosis (prePMF) and essential thrombocythemia (ET) in the community setting. ....

United States , Andrew Srisuwananukorn , Ohio State University Comprehensive Cancer Center , American Society Of Hematology Annual Meeting , Hematology Annual Meeting , Primary Myelofibrosis , Essential Thrombocythemia ,

Adding Navitoclax to Ruxolitinib Doubles Spleen Volume Reductions for Myelofibrosis

Up-front treatment with navitoclax plus ruxolitinib significantly reduced spleen volume by 35% or more at week 24 vs ruxolitinib plus placebo in patients with myelofibrosis; however, a significant difference was not observed in total symptom score v. 4.0 between the arms, according to data from the phase 3 TRANSFORM-1 study. ....

United States , Naveen Pemmaraju , Department Of Leukemia , University Of Texas Md Anderson Cancer Center , Cancer Center , Navitoclax Plus Ruxolotinib , Ash Annual Meeting , Transform 1 Study , Md Anderson ,

COMING SOON: Advances in Myelofibrosis Treatment and Enhancing Patient Quality of Life

Christine Cooper, RN, BSN, provides a preview of an upcoming CURE Expert Connections program discussing advancements in the care of myelofibrosis, including improved outcomes and quality-of-life for patients. ....

Christine Cooper , Myelofibrosis Treatment , Enhancing Patient Quality , Cure Expert Connections , Myelofibrosis Care , Myelofibrosis Treatments , Myelofibrosis Treatment Advances ,