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Scientists uncover cellular cause of heart defects in babies born to women with diabetes

When women with diabetes become pregnant, they face not only the typical challenges of pregnancy and impending parenthood, but also a scary statistic: they're five times more likely to have a baby with a congenital heart defect. ....

United States , Lyandysha Zholudeva , Irina Sattui , Arun Padmanabhan , Benjamin Van Soldt , Angelo Pelonero , Feiya Li , Michael Alexanian , Tomohiro Nishino , Yu Huang , Nandhini Sadagopan , Frances Koback , Casey Gifford , Van Bemmel , Reuben Thomas , Sanjeev Ranade , Deepak Srivastava , Michael Antonov Charitable Foundation , American Heart Association Postdoctoral Fellowship , Lk Whittier Foundation , National Institutes Of Health , Nature Cardiovascular Research , Gladstone Roddenberry Stem Cell Center , Roddenberry Foundation , Nature Cardiovascular Research On , Younger Family Fund ,

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer's disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function without changes in food intake or daily activity. ....

United States , G William Wong , Susana Rodriguez , Christian Oeing , David Kass , Vivek Jani , Dylan Sarver , Brian Orourke , Emily Henderson , Nandhini Sadagopan , Brittany Dunkerly , Sheila Collins , John Gangoiti , Hildur Knutsdottir , Deepthi Ashok , Sumita Mishra , Ryan Ceddia , Sean Murphy , Dorothy Sears , Johns Hopkins University , University Of California San Diego , Us Centers For Disease , Pfizer Inc , Vanderbilt University , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine ,

Cousin of Viagra Reduces Obesity by Stimulating Cells to Burn Fat, Study Shows

After being placed on high-fat diets, mice were either selected to take the PDE9 inhibiting oral drug or a placebo. The PDE9 inhibitor reduced total ....

United States , G William Wong , Susana Rodriguez , Christian Oeing , David Kass , Vivek Jani , Dylan Sarver , Brian Orourke , Nandhini Sadagopan , Brittany Dunkerly , Sheila Collins , John Gangoiti , Hildur Knutsdottir , Deepthi Ashok , Sumita Mishra , Ryan Ceddia , Sean Murphy , Dorothy Sears , Johns Hopkins University , University Of California San Diego , Us Centers For Disease , Pfizer Inc , Vanderbilt University , Johns Hopkins University School Of Medicine , Johns Hopkins Medicine , Clinical Investigation ,

Flipping a Molecular Switch for Heart Fibrosis

Flipping a Molecular Switch for Heart Fibrosis
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