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On December 22, 2023, President Biden issued a new Executive Order (E.O.) amending E.O. 14024 and E.O. 14068. This E.O. further targets Russian sanctions evasion and solidifies...
In a repeated-measures study conducted between 2018-2021 in 7 semi-rural parishes of Quito, Ecuador, Heather Kathleen Amato and colleagues aim to identify determinants of antibiotic resistant E.coli infection in children.
The Florida Department of Environmental Protection's (DEP) Historic Shoreline Database contains many directories of related types of information about beach changes in Florida over the past 150 or so years and continues to be updated as new surveys are processed.
2022 Survey :: Haskell Weekly haskellweekly.news - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from haskellweekly.news Daily Mail and Mail on Sunday newspapers.
GAITHERSBURG, Md., June 07, 2022 (GLOBE NEWSWIRE) -- GL Communications Inc., a global leader in telecom test and measurement solutions, addressed the...
A substantial proportion of the adult US population with type 2 diabetes (T2D) are undiagnosed, calling into question the comprehensiveness of current screening practices, which primarily rely on age, family history, and body mass index (BMI). We hypothesized that a polygenic score (PGS) may serve as a complementary tool to identify high-risk individuals. The T2D PGS maintained predictive utility after adjusting for family history and combining genetics with family history led to even more improved disease risk prediction. We observed that the PGS was meaningfully related to age of onset with implications for screening practices: there was a linear and statistically significant relationship between the PGS and T2D onset (-1.3 years per standard deviation of the PGS). Evaluation of U.S. Preventive Task Force and a simplified version of American Diabetes Association screening guidelines showed that addition of a screening criterion for those above the 90th percentile of the PGS provided a small increase the sensitivity of the screening algorithm. Among T2D-negative individuals, the T2D PGS was associated with prediabetes, where each standard deviation increase of the PGS was associated with a 23% increase in the odds of prediabetes diagnosis. Additionally, each standard deviation increase in the PGS corresponded to a 43% increase in the odds of incident T2D at one-year follow-up. Using complications and forms of clinical intervention (i.e., lifestyle modification, metformin treatment, or insulin treatment) as proxies for advanced illness we also found statistically significant associations between the T2D PGS and insulin treatment and diabetic neuropathy. Importantly, we were able to replicate many findings in a Hispanic/Latino cohort from our database, highlighting the value of the T2D PGS as a clinical tool for individuals with ancestry other than European. In this group, the T2D PGS provided additional disease risk information beyond that offered by traditional screening methodologies. The T2D PGS also had predictive value for the age of onset and for prediabetes among T2D-negative Hispanic/Latino participants. These findings strengthen the notion that a T2D PGS could play a role in the clinical setting across multiple ancestries, potentially improving T2D screening practices, risk stratification, and disease management.
Fintech regulations, financial stability, and data privacy: So, what is the path to go forward? January 27, 2021, 9:14 PM IST Anand Kumar, founder of Pier Counsel In a recent development, the Delhi High Court received a Public Interest Litigation (PIL) from an applied economist, Reshmi P Bhaskaran, seeking to regulate the entry and operations of ‘TechFin’ platforms. Inter alia, the PIL asked the High Court to help develop a regulatory framework around the TechFin industry, also popularly known as the FinTech domain. Since then, the High Court has sought replies from various stakeholders, including the Ministry of Law, Ministry of Finance, RBI, SEBI, and NPCI regarding this issue.