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 E-Mail Researchers from the Hong Kong University of Science and Technology (HKSUST) and the University of Hong Kong (HKU) recently demonstrated that the selectivity determinant of Origin Recognition Complex (ORC) for DNA binding lies in a 19-amino acid insertion helix in the Orc4 subunit, which is present in yeast but absent in human. Removal of this motif from Orc4 transforms the yeast ORC, which selects origins based on base-specific binding at defined locations, into one whose selectivity is dictated by chromatin landscape (genomic nucleosome profile), a characteristic feature shared by...

Improper DNA division leads to human developmental disorder: Study ANI | Updated: Dec 15, 2020 10:36 IST Birmingham [UK], December 15 (ANI): A recent study by University of Alabama at Birmingham describes a rare genetic developmentdisorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities in humans. The research published as a highlighted article in the Journal Genetics used fruit fly model to reveal about 'Meier-Gorlin' syndrome, or MGS, which is a rare genetic developmental disorder like dwarfism other ske...

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome Meier-Gorlin syndrome, or MGS, is a rare genetic developmental disorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities. In severe cases, MGS results in miscarriages and stillbirths. Igor Chesnokov, Ph.D., and his University of Alabama at Birmingham colleagues study this recessive, autosomal disorder in an unusual way -- by placing mutant human genes into fruit flies. Specifically, they look at one of the genes involved in MGS called Orc6. In a study published in Ge...