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Novel insights from the pandemic may be propelling the field of immunology into a new golden age.

Novel insights from the pandemic may be propelling the field of immunology into a new golden age.

The global COVID-19 vaccination campaign saved an estimated 20 million lives. However, while current COVID-19 vaccines provide protection against developing severe disease, they do little to prevent infection and transmission.

<p>Findings published in the journal <em><a href="https://www.nature.com/articles/s41586-023-06951-3">Nature</a> </em>by physician-scientists at Beth Israel Deaconess Medical Center (BIDMC) and colleagues suggest that it may be possible to improve protection against COVID-19 by delivering the vaccine directly to the respiratory tract&mdash; the primary site of entry in SARS-CoV-2 infection.</p>

<p>A new study by investigators from <a href="https://www.massgeneralbrigham.org/">Mass General Brigham</a> found that one in five individuals taking Nirmatrelvir-ritonavir therapy, commonly known as Paxlovid, to treat severe symptoms of COVID-19, experienced a positive test result and shedding of live and potentially contagious virus following an initial recovery and negative test&mdash;a phenomenon known as virologic rebound. By contrast, people not taking Paxlovid only experienced rebound about 2 percent of the time. Results are published in <a href="...