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Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict before treatment begins how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. ....

Dana Farber Cancer Institute , United States , Memorial Sloan Kettering Cancer Center , New York , Beth Israel Medical Center , Sabina Signoretti , Emily Henderson , Ezra Baraban , Michael Atkins , Jaroslaw Jerdych , Saurabh Gupta , David Mcdermott , Suzannel Topalian , Robertj Motzer , Tonik Choueiri , Janis Taube , Evanj Lipson , Ludmila Danilova , Julie Stein Deutsch , Bristol Myers Squibb , Bloomberg Kimmel Institute For Cancer Immunotherapy , Johns Hopkins Kimmel Cancer Center , Beth Israel Deaconess Medical Center , Tumor Microenvironment Laboratory , Division Of Dermatopathology , Georgetown Lombardi Comprehensive Cancer Center ,