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Credit: Irene Böttcher-Gajewski / Max Planck Institute for Biophysical Chemistry The award is one of the most prestigious in Europe and endowed with 500,000 Swiss francs. With this prize the Louis-Jeantet Foundation honors the director at the Max Planck Institute (MPI) for Biophysical Chemistry for his pioneering work in the field of gene transcription. Transcription is a copying process enabling living cells to produce transcripts of their genes that then serve as blueprints for making proteins. Cramer's research focuses on the molecular machines, called RNA polymerases, that control this f...

Date Time Coronavirus: Weak Point of Remdesivir The drug Remdesivir only weakly inhibits the new coronavirus SARS-CoV-2. Research groups from Göttingen and Würzburg have discovered why this is so. The Covid-19 drug Remdesivir (purple) is incorporated into the new RNA chain during the copying process and suppresses the duplication of the coronavirus genome. (Image: Hauke Hillen, Goran Kokic, Patrick Cramer / Max-Planck-Institut für biophysikalische Chemie Göttingen) Remdesivir is the first drug against Covid-19 to be conditionally approved in Europe and the United States. The drug is desi...

Credit: Hauke S. Hillen A newly developed compound starves cancer cells by attacking their "power plants" - the so-called mitochondria. The new compound prevents the genetic information within mitochondria from being read. Researchers from the Max Planck Institute for Biology of Ageing in Cologne, the Karolinska Institute in Stockholm and the University of Gothenburg report in their study that this compound could be used as a potential anti-tumour drug in the future; not only in mice but also in human patients. Mitochondria provide our cells with energy and cellular building blocks necessary ...

Researchers at Karolinska Institutet in Sweden report in the journal Nature that they have developed novel first-in-class inhibitors that compromise mitochondrial function in cancer cells. Treatment with the inhibitors stopped cancer cells from proliferating and reduced tumour growth in mice, without significantly affecting healthy cells. "We are excited to have shown that this novel principle for cancer treatment works in animal models and hopefully the inhibitors can now be developed further for anti-cancer treatment in humans," says Nils-Göran Larsson, professor at the Department of Medi...