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Popular diabetes drugs not linked to thyroid cancer risk, study finds

Drugs known as GLP-1 analogs have become increasingly popular to treat diabetes and obesity, but there have been concerns that they might increase the risk of thyroid cancer.

Norway , Sweden , Solna , Stockholm , Denmark , Swedish , Peter-ueda , Karolinska-institutet , Department-of-medicine , Swedish-cancer-society , Swedish-research-council , Cancer

Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study

Objective To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer.

Design Scandinavian cohort study.

Setting Denmark, Norway, and Sweden, 2007-21.

Participants Patients who started GLP1 receptor agonist treatment were compared with patients who started dipeptidyl peptidase 4 (DPP4) inhibitor treatment, and in an additional analysis, patients who started sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment.

Main outcome measures Thyroid cancer identified from nationwide cancer registers. An active-comparator new user study design was used to minimise risks of confounding and time related biases from using real world studies of drug effects. Cox regression was used to estimate hazard ratios, controlling for potential confounders with propensity score weighting.

Results The mean follow-up time was 3.9 years (standard deviation 3.5 years) in the GLP1 receptor agonist group and 5.4 years (standard deviation 3.5 years) in the DPP4 inhibitor group. 76 of 145 410 patients (incidence rate 1.33 events per 10 000 person years) treated with GLP1 receptor agonists and 184 of 291 667 patients (incidence rate 1.46 events per 10 000 person years) treated with DPP4 inhibitors developed thyroid cancer. GLP1 receptor agonist use was not associated with increased risk of thyroid cancer (hazard ratio 0.93, 95% confidence interval 0.66 to 1.31; rate difference −0.13, 95% confidence interval −0.61 to 0.36 events per 10 000 person years). The hazard ratio for medullary thyroid cancer was 1.19 (0.37 to 3.86). In the additional analysis comparing the GLP1 receptor agonist group with the SGLT2 inhibitor group, the hazard ratio for thyroid cancer was 1.16 (0.65 to 2.05).

Conclusions In this large cohort study using nationwide data from three countries, GLP1 receptor agonist use was not associated with a substantially increased risk of thyroid cancer over a mean follow-up of 3.9 years. In the main analysis comparing GLP1 receptor agonists with DPP4 inhibitors, the upper limit of the confidence interval was consistent with no more than a 31% increase in relative risk.

No additional data available. The data analysed in this study were based on Scandinavian nationwide register. Individual level data from the registers can only be accessed through secure servers and only export of aggregated data, as presented in research articles, is allowed. Permission to access data can be made only after fulfilling specific requirements to safeguard the anonymity of the study participants and other data safety issues. For these reasons, data cannot be made generally available.

Norway , Denmark , France , United-states , Sweden , Danish , French , Swedish , Karolinska-institutet , Eli-lilly , Drottning-victorias-frimurarestiftelse , Konung-gustaf

Twins Study Sheds Light on In-Womb Immune Defence

Twins Study Sheds Light on In-Womb Immune Defence
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Huddinge , Stockholm , Sweden , Swedish , Karolinska-institutet , Jonna-bister , Swedish-cancer-society , Centre-for-innovative-medicine-at-karolinska-institutet , European-union-horizon , Alice-wallenberg-foundation , Swedish-society-for-medical-research , Novo-nordisk-foundation

Less extensive breast cancer surgery results in fewer swollen arms

Less extensive breast cancer surgery results in fewer swollen arms
sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.

Sweden , Swedish , Karolinska-institutet , Swedish-research-council , Department-of-molecular-medicine , Swedish-cancer-society , Nordic-cancer-union , Swedish-breast-cancer-association , Jana-de-boniface , Molecular-medicine , Swedish-breast-cancer ,

Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI

This preliminary descriptive report compares the rates of detecting high- and low-grade prostate cancer in men invited for prostate cancer screening vs

Helsinki , Eteläuomen-läi , Finland , Paris , France-general- , France , United-kingdom , Ronkainen , Northern-ostrobothnia , Sweden , Arvo , Kainuu-region

Fewer Swollen Arms with Less Invasive Breast Cancer Surgery

Fewer Swollen Arms with Less Invasive Breast Cancer Surgery
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Sweden , Swedish , Sophie-norenstedt , Michalis-kontos , Toralf-reimer , Jan-frisell , Yvette-andersson , Dan-lundstedt , Oreste-davide-gentilini , Roger-olofsson-bagge , Johan-ahlgren , Inge-scheel-andersen

Incidence of oncogenic HPV infection in women with and without mental illness: A population-based cohort study in Sweden

Author summary Why was this study done? Mental illness has been associated with a higher risk of cervical cancer and precancerous lesions as well as a lower degree of participation in cervical screening. Little is known, however, regarding disparities in HPV infection between women with and without mental illness. What did the researchers do and find? In a cohort study, we followed all 337,116 women who were at age 30 to 64, living in Stockholm, and had a negative test result of high-risk HPV during August 2014 to December 2019, to assess the link between mental illness and risk of infection with high-risk HPV. The absolute infection rate of HPV was 45% higher among women with a specialist diagnosis of mental disorder and 67% higher among women with a filled prescription of psychotropic medications, compared to women without such. What do these findings mean? Mental illness is associated with an increased infection rate of oncogenic HPV in women. Refined approaches are needed to facilitate the elimination agenda of cervical cancer among women with mental illness.

United-states , Sweden , North-carolina , Texas , Stockholm , New-jersey , Swedish , Wei-zheng , International-classification-of-diseases , Swedish-national-cervical-screening-registry-nkcx , Swedish-cancer-society , Swedish-national-board-of-health

Breakthrough Method Detects Early Myelodysplastic Syndrome Relapse

Breakthrough Method Detects Early Myelodysplastic Syndrome Relapse
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Norway , Denmark , Sweden , Uppsala , Uppsala-lan , Finland , Huddinge , Stockholm , Swedish , Magnus-tobiasson , Karolinska-institutet , Swedish-cancer-society

Protein Insight May Lead to New Cancer Treatments

Protein Insight May Lead to New Cancer Treatments
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Sweden , Swedish , Dilraj-lama , Lennart-nilsson , Kaare-teilum , Thibault-vosselman , Marie-arsenian-henriksson , Michael-landreh , Carmine-cerrato-marie-arsenian-henriksson , Cagla-sahin , Karolinska-institutet , Carminep-cerrato

HILPDA Protein: Potential Biomarker for Aggressive Kidney Cancer Treatment

HILPDA Protein: Potential Biomarker for Aggressive Kidney Cancer Treatment
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Sweden , Swedish , Lourdes-sainero-alcolado , Karolinska-institutet , Marie-arsenian-henriksson , Radiumhemmet-research-funds , Swedish-childhood-cancer-foundation , Swedish-cancer-society , Robert-lundberg-memorial-foundation , Wallenberg-academy-fellowship , Lourdes-sainero ,