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Mutations in AGC kinase motif linked to colorectal cancer growth

Cancer spreads throughout the human body in cunning, almost militaristic, ways. For example, it can manipulate our genetic make-up, take over specific cell-to-cell signaling processes, and mutate key enzymes to promote tumor growth, resist therapies, and hasten its spread from the original site to the bloodstream or other organs. ....

Jianfeng Chen , Pengda Liu , Lily Ramsey , Department Of Biostatistics , Lineberger Comprehensive Cancer Center , Department Of Biochemistry , Gillings School Of Public Health , Comprehensive Cancer Center , Experimental Medicine , Cancer Genome Atlas , Xianming Tan , Gillings School , Public Health , Lineberger Comprehensive Cancer ,

Researchers discover new mechanism to understand role of mutations on enzyme substrates

Researchers discover new mechanism to understand role of mutations on enzyme substrates
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Jianfeng Chen , Pengda Liu , Lineberger Comprehensive Cancer Centre , Department Of Biostatistics , Gillings School Of Public Health , Lineberger Comprehensive Cancer Center , Department Of Biochemistry , Comprehensive Cancer Centre , Cancer Genome Atlas , Xianming Tan , Gillings School , Public Health , Lineberger Comprehensive Cancer ,

Researchers discover cancer hijacks a class of enzyme motif mutations to fuel tumorigenesis

Researchers discover cancer hijacks a class of enzyme motif mutations to fuel tumorigenesis
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Pengda Liu , Jianfeng Chen , Department Of Biostatistics , Gillings School Of Public Health , Lineberger Comprehensive Cancer Center , Department Of Biochemistry , Comprehensive Cancer Center , Experimental Medicine , Cancer Genome Atlas , Xianming Tan , Gillings School , Public Health , Lineberger Comprehensive Cancer ,