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Revvity beats quarterly estimates on demand for diagnostic equipment

Revvity on Monday beat
Wall Street estimates for its quarterly profit and revenue,
helped by better-than-expected demand for equipment in its
diagnostics unit.
Contract drug. ....

United States , Vijay Kishore , Puyaan Singh , Wall Street ,

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions1. TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impaired interneuron migration, activity-dependent dendrite retraction and an unanticipated persistent expression of exon 8A2–6. We reasoned that switching CACNA1C exon utilization from 8A to 8 would represent a potential therapeutic strategy. Here we developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells both in vitro and, following transplantation, in vivo. We discovered that the ASO-mediated switch from exon  ....

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Posting Patient Prices: Transparency Cure for Hospital Blank Checks

Posting Patient Prices: Transparency Cure for Hospital Blank Checks
ricochet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ricochet.com Daily Mail and Mail on Sunday newspapers.

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