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A team of researchers led by Feng Zhang at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT has uncovered the first programmable RNA-guided system in eukaryotes — organisms that include fungi, plants, and animals. In a study in Nature, the team describes how the system is based on a protein called Fanzor. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. The compact Fanzor systems have the potential to be more easily delivered to cells and tissues as t...

Researchers have discovered the first programmable RNA-guided system discovered in eukaryotes. The technology, known as Fanzor, has the potential to be more easily delivered to cells and tissues than CRISPR-Cas systems, and further refinements could make them a valuable new technology for human genome editing.

Signature Theatre has revealed its Winter/Spring 2024 season, with work from resident playwrights Dominique Morisseau, Sarah Ruhl, and Dave Malloy.

Signature Theatre announces the cast and creative team of its world premiere production of MacArthur Fellow Branden Jacobs-Jenkins' The Comeuppance, directed by Eric Ting. Concluding Jacobs-Jenkins' Premiere Residency—and Signature's 2022-2023 season of personal and profound works from its Resident writers—The Comeuppance runs May 16–June 25.

Researchers have developed a new protein delivery approach that works in human cells and animals. The system could be a safe and efficient way to deliver gene therapies and cancer therapies.