Ibrutinib Plus Venetoclax With MRD-Directed Duration of Treatment Is a New Standard-of-Care Regimen for Previously Unmanaged CLL
The MRD-guided treatment approach has a significant advantage over chemotherapy.
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The MRD-guided treatment approach has a significant advantage over chemotherapy.
Personalized treatment for the most common form of adult leukemia helps patients survive for longer and stay in remission, a phase III trial has found.
The ibrutinib-venetoclax combination was particularly effective in patients with chronic lymphocytic leukemia with high-risk features such as IGHV unmutated disease or chromosomal abnormalities.
Personalized, time-limited regimen of venetoclax plus ibrutinib improves survival versus FCR
This is the first trial to show that a MRD-guided approach with treatment beyond MRD negativity has a significant advantage over chemotherapy, both in terms of PFS and OS.