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Investigating a population in southern Sweden, a new study has found that a single dose of the vaccine is only about 42% effective in preventing coronavirus disease 2019 (COVID-19). But seven days after the second dose, the vaccine can prevent COVID-19 in 86% of the population.
Interfering RNA nanoparticles could be a potential COVID-19 therapy Study shows lipid nanoparticle-based siRNA is potent in suppressing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – in cells as well as in mice models. COVID-19 cases continue to increase all over the world. Several vaccines have now been approved and are being administered. However, with new variants of the virus emerging, there have been questions around how effective the vaccines will be. The genome in coronaviruses is encoded by ribonucleic...
Modeling study suggests how different SARS-CoV-2 mutations prevent antibody binding Using three classes of antibodies, researchers modeled their binding to the SARS-CoV-2 virus spike protein. They found binding to key residues in current mutations changes how the spike protein moves and can lead to binding resistance. The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adopts several conformations when it binds to host receptors. Antibodies against the virus often compete with the host receptors to bind to the spike protein and interfere with the processes th...
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Speed of vaccination is key to reducing COVID-19 spread, says study Mathematical modeling of the effects of vaccine efficacy and the speed of vaccination show that a lower efficacy vaccine may curb disease transmission similar to that of a higher efficacy vaccine if the speed of immunization is high. To combat the COVID-19 pandemic, several vaccines have now been approved and are being administered to populations across the globe. However, one concern has been the vaccines' efficacy against emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These vaccines ...
The spike protein is the main part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the infection. It consists of two subunits S1 and S2. Upon entry of the virus into the human body, the S1 subunit helps the virus bind to the angiotensin-converting enzyme 2 (ACE2) receptors on host cells.