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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia. ....

United States , Baylor College Of Medicine , Jun Li , Wei Li , Xing Fang , Lingyong Li , Zeinab Mehsein , Changqun Yao , Kimberley Tolias , National Institutes Of Health , Department Of Anesthesiology , Mission Connect , Department Of Neurobiology , Marnixe Heersink School Of Medicine , University Of Alabama At Birmingham , Baylor College , Associate Professor , Clinical Investigation , Perioperative Medicine , National Institutes , Chronic Pain , Ouse Model , Neuropathic Pain , Pain Management ,

Compass Surgical's year: 6 moves in 4 months

"Discover the latest moves from ASC management company Compass Surgical Partners in 2024, including new partnerships and equity investments." ....

United States , Bon Secours , Baptist Health , Spine Institute Orlando , Bon Secours Mercy Health , S Millennium Surgery Center , Horizon Surgery Center , Compass Surgical Partners , Cincinnati Based Bon Secours Mercy Health , Millennium Surgery Center , Short Pump , Advanced Joint , Secours Mercy Health , Jacksonville Beach , Horizon Surgery , Compass Surgical , Bsc Management , Compass Surgical Partners , Equity Investments , Pain Management , Joint Replacement , Interventional Pain Management , Plastic Surgery , Ob Gyn ,

California and Nevada fishing report through April 25

Here is the fishing report for rivers, lakes and streams in Nevada, Northern California, Lake Tahoe and the Sierra. This report is for the week of April 18-25, 2012. The opening day for all California fishing is on April 28. ....

United States , Carson River , Squaw Creek , Little River , Convict Lake , East Walker River , Hobart Reservoir , Hot Creek , West Carson , Cave Rock , Mineral County , Wild Horse , Lincoln County , Virginia Lakes , Topaz Lake , Fall River , New Zealand General , New Zealand , Hares Ears , Canyon Reservoir , Twin Lakes , Heenan Lake , Overton Arm , Owens River Gorge , Smith River , Pine Valley ,

Weather Service: Cooler temperatures, snow showers unlikely for Carson City, Lake Tahoe

A cold front will continue to push through the region late Saturday night into Monday but it looks like it will miss Lake Tahoe and Carson City with only a slight chance of rain and snow showers with the brunt of the system heading further into central and southern Nevada and the California Eastern Sierra to the south, according to the National Wea ....

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Don Q's Fishing Report for the week of Sept. 5-11

Here is this week s fishing report for Nevada, Northern California and Sierra area rivers, lakes and streams. Fall colors are around the corner for the Sierra and Lake Tahoe region. Enjoy the fishing while the weather is still good and don t forget to pack your sunscreen and fishing license. This report is for the week of Sept. 5-11. ....

United States , Windy Point , San Joaquin , French Meadows Reservoir , King Salmon , East Walker River , Balls Ferry , Dry Creek , Convict Lake , Davis Dam , Washoe Lake , George Lake , Big Springs , Pleasant Valley Reservoir , Red Bluff , Trinity River , Hot Creek , Frenchman Lake , Coos Bay , Bridgeport Reservoir , Feather River , North Lake , Crooked Creek , Lincoln County , Blake Britton , South Lake ,