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Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

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Morphine tolerance results from Tiam1-mediated maladaptive plasticity in spinal neurons

Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine’s utility in chronic pain management. Understanding the mechanisms underlying tolerance and hyperalgesia is essential to...

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Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes

Morphine Tolerance Linked to Tiam1-Mediated Neuron Changes
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How 'Mr Perfect' Dr Andrew Huberman went from counselling millions on self-discipline to being caught cheating with five lovers

Podcaster is accused of having five lovers while undergoing IVF with girlfriend

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Yoga And Mindfulness-Based Therapy Can Help Stressed Out Employees Improve Their Quality Of Life

Yoga And Mindfulness-Based Therapy Can Help Stressed Out Employees Improve Their Quality Of Life
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Arrested student speaks out following emergency protest

Arrested student speaks out following emergency protest
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'Wellness bro' Andrew Huberman is accused of lying to women he dates. Does it matter to his millions of listeners? | Arwa Mahdawi

The Stanford neuroscientist is highly credentialed and endearingly earnest on his popular wellness podcast, but is now facing claims against his credibility

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Who Is Podcast Guest Turned Star Andrew Huberman, Really?

Stanford’s Andrew Huberman rose to prominence as a guest on the shows of Joe Rogan, Jordan Peterson, Rich Roll, and others. His podcast, Huberman Lab, has millions of followers. But his former girlfriends say he has a controlling, manipulative side.

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Flexible due dates lower student stress without loss of rigor

Flexible due dates lower student stress without loss of rigor
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Flexible due dates lower student stress without loss of rigor

Flexible due dates lower student stress without loss of rigor
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