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New standards for plasma proteomics—Balancing throughput for large sample cohorts and depth of analysis for biomarker discovery

Plasma is a rich source for protein biomarkers that can be used to reveal disease biology, measure responses to therapeutic treatments, or for diagnostic and prognostic purposes. A major advantage of plasma proteomics is the convenience of obtaining samples from routine blood draws and the availability of large cohorts of samples stored awaiting analysis such as in biobanks. However, identifying these biomarkers with bottom-up proteomics has substantial c ....

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