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Comparative analysis of SARS-CoV-2 antivirals leads to new potential treatment for COVID-19


Comparative analysis of SARS-CoV-2 antivirals leads to new potential treatment for COVID-19
A rapid spread of the virus that caused symptoms similar to severe pneumonia was first reported in Wuhan, China, in December 2019. Scientists found that this novel virus belonged to the family Coronaviridae and was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Worldwide, researchers are developing various vaccines, medicines, facemasks, and many other means to contain the SARS-CoV-2 infection.
Among various antiviral drugs, remdesivir has been approved for the treatment of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection. Remdesivir is a nucleoside analog that inhibits the SARS-CoV-2 RNA-dependent RNA-polymerase (RdRp). It is a virus polymerase inhibitor that involves the termination of both the viral transcript and newly synthesized viral genomes. However, there are some limitations that have escalated the need to develop other potenti ....

Priyom Bose , Ekaterina Bondaretc Shutterstock , Ekaterina Bondaretc , Multi Drug Resistance Protein , Antiviral Drug , Coronavirus Disease Covid 19 , Drug Repurposing , Sars Cov 2 , Corona Virus , In Vitro , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , பிரீயோம் போஸ் , பல மருந்து எதிர்ப்பு ப்ரோடீந் , மருந்து மறுபயன்பாடு , கொரோனா வைரஸ் , இல் விட்ரோ , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater


High-throughput sequencing could allow detection of new SARS-CoV-2 variants in wastewater
As new variants emerge of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen causing the current coronavirus disease 2019 (COVID-19) pandemic, continue to circulate, early identification and sequencing have become a necessary part of research in this area. This virus is known to be shed from the nose, the lungs, the saliva, urine, and feces.
A new study, published on the
medRxiv preprint server, reports the use of metagenomics to detect the virus from wastewater samples, indicating community-level circulating variants that are not yet identified or are present in very low proportions on clinical databases. ....

Liji Thomas , Wastewater By High Throughput , Image Credit , People Image Studio , Wastewater Based Epidemiology , Coronavirus Disease Covid 19 , High Throughput Sequencing , Sars Cov 2 , Amino Acid , Corona Virus , Genomic Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , படம் கடன் , மக்கள் படம் ஸ்டுடியோ , கழிவு நீர் அடிப்படையிலானது தொற்றுநோய் , அமினோ அமிலம் , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,