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People Aged Over 105 may Have More Efficient DNA Repair


People Aged Over 105 may Have More Efficient DNA Repair
by Angela Mohan on 
May 5, 2021 at 8:54 AM
eLife.
These people have had their genomes decoded in a detailed manner first time, providing clues as to why they live so long.br>
Aging is a common risk factor for several chronic diseases and conditions, explains Paolo Garagnani, Associate Professor at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy, and a first author of the study.
We chose to study the genetics of a group of people who lived beyond 105 years old and compare them with a group of younger adults from the same area in Italy, as people in this younger age group tend to avoid many age-related diseases and therefore represent the best example of healthy aging. ....

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Is There a Link Between DNA and Marriage Satisfaction?


Is There a Link Between DNA and Marriage Satisfaction?
by Hannah Joy on 
February 19, 2021 at 1:29 PM
Newlyweds with higher levels of CC variation have successful relationships, as they are more grateful for their partner, have higher levels of trust more forgiving and are more satisfied with their marriages, according to a new study conducted by a University of Arkansas psychologist.
Recent research indicates that a variation called CC in the gene CD38 is associated with increased levels of gratitude.
Extending that line of work, U of A psychologist Anastasia Makhanova and her colleagues used data from a study of genotyped newlyweds to explore whether a correlation existed between the CD38 CC variation and levels of trust, forgiveness and marriage satisfaction. ....

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Designer DNA Helps Treat Multiple Myeloma in Mice


Designer DNA Helps Treat Multiple Myeloma in Mice
by Angela Mohan on 
January 21, 2021 at 12:20 PM
Targeted approach helps to treat myeloma by silencing IRF4, a gene that allows myeloma stem cells and tumor cells to proliferate and survive.
Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease, as per the team of researchers at University of California San Diego School of Medicine and Ionis Pharmaceuticals.
Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That s in part because cancer stem cells drive the disease cells that continually self-renew. If a therapy can t completely destroy these malignant stem cells, the cancer is likely to keep coming back. ....

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