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Health: People who live past 105 have bodies that are more efficient at mending DNA


People who live for more than 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, a study has found.
Researchers compared the sequenced genomes of 81 Italians aged 105 and over with healthy adults from the same region that were aged around 68.
They found that certain genetic changes, which were linked to DNA repair, cellular health and the death of damaged cells, were more common in people aged over 105.
The team said that the study represents the first time that the genomes of people with extreme longevity have been decoded in such fine detail. ....

Cristina Giuliani , Massimo Delledonne , Claudio Franceschi , Vladimir Khavinson , Jeanne Calment , Paolo Garagnani , University Of Verona , Petersburg Institute Of Bioregulation , United Nations , University Of Bologna , Office For National Statistics , National Statistics , Frenchwoman Jeanne Calment , Petersburg Institute , Professor Khavinson , கிறிஸ்டினா கியுலியானி , கிளாடியோ பிரான்செச்சி , பல்கலைக்கழகம் ஆஃப் வெரோனா , ஒன்றுபட்டது நாடுகள் , பல்கலைக்கழகம் ஆஃப் போலோக்னா , அலுவலகம் க்கு தேசிய புள்ளிவிவரங்கள் , தேசிய புள்ளிவிவரங்கள் , பீட்டர்ஸ்பர்க் நிறுவனம் ,

People Aged Over 105 may Have More Efficient DNA Repair


People Aged Over 105 may Have More Efficient DNA Repair
by Angela Mohan on 
May 5, 2021 at 8:54 AM
eLife.
These people have had their genomes decoded in a detailed manner first time, providing clues as to why they live so long.br>
Aging is a common risk factor for several chronic diseases and conditions, explains Paolo Garagnani, Associate Professor at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy, and a first author of the study.
We chose to study the genetics of a group of people who lived beyond 105 years old and compare them with a group of younger adults from the same area in Italy, as people in this younger age group tend to avoid many age-related diseases and therefore represent the best example of healthy aging. ....

Cristina Giuliani , Massimo Delledonne , Claudio Franceschi , Paolo Garagnani , Environmental Sciences , University Of Verona , Department Of Experimental , Laboratory Of Molecular Anthropology , University Of Bologna , Associate Professor , Specialty Medicine , Senior Assistant Professor , Molecular Anthropology , Full Professor , Professor Emeritus , Free Radicals Cell , Printinggenetic Testing , Diseasesepigeneticsoxidative Stress , கிறிஸ்டினா கியுலியானி , கிளாடியோ பிரான்செச்சி , சுற்றுச்சூழல் அறிவியல் , பல்கலைக்கழகம் ஆஃப் வெரோனா , துறை ஆஃப் சோதனை , பல்கலைக்கழகம் ஆஃப் போலோக்னா , இணை ப்ரொஃபெஸர் , சிறப்பு மருந்து ,

Do people aged 105 and over live longer because they have more efficient DNA repair?


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Researchers have found that people who live beyond 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, according to a study published today in
eLife.
This is the first time that people with extreme longevity have had their genomes decoded in such detail, providing clues as to why they live so long and manage to avoid age-related diseases.
Aging is a common risk factor for several chronic diseases and conditions, explains Paolo Garagnani, Associate Professor at the Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy, and a first author of the study. We chose to study the genetics of a group of people who lived beyond 105 years old and compare them with a group of younger adults from the same area in Italy, as people in this younger age group tend to avoid many age-related diseases and therefore represent the best example of healthy aging. ....

Cristina Giuliani , Massimo Delledonne , Claudio Franceschi , Emily Packer , Paolo Garagnani , Environmental Sciences , Research In Lausanne , University Of Verona , Department Of Experimental , Laboratory Of Molecular Anthropology , University Of Bologna , Associate Professor , Specialty Medicine , Patrick Descombes , Senior Assistant Professor , Molecular Anthropology , Full Professor , Professor Emeritus , Special Issue , Media Relations Manager , Medicine Health , கிறிஸ்டினா கியுலியானி , கிளாடியோ பிரான்செச்சி , எமிலி ப்யாகர் , சுற்றுச்சூழல் அறிவியல் , பல்கலைக்கழகம் ஆஃப் வெரோனா ,