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Structure of DNA is found to be actively involved in genome regulation


University of Seville
The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later. The paper that has now been published by the team led by Felipe Cortés, head of the DNA Topology and Breaks Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with Silvia Jimeno González, professor at the University of Seville and head of the mRNA Transcription and Processing Group at the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), shows that this supercoiling characteristic of DNA’s structure controls gene expression rather than being a mere collateral damage to be solved, as had been thought to date. The results are reporte ....

Spain General , Silvia Jimeno Gonz , Felipe Cort , Andalusian Centre For Molecular Biology , University Of Seville , Health Institute , Spanish National Cancer Research Centre , Spanish Association Against Cancer , European Research Council , Processing Group , Ministry Of Science , Breaks Group , Andalusian Centre , Molecular Biology , Regenerative Medicine , Spanish Association Against , ஸ்பெயின் ஜநரல் , ஃபெலிப் கோர்ட் , பல்கலைக்கழகம் ஆஃப் செவில்லே , ஆரோக்கியம் நிறுவனம் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , ஸ்பானிஷ் சங்கம் எதிராக புற்றுநோய் , ஐரோப்பிய ஆராய்ச்சி சபை , ப்ரோஸெஸிஂக் குழு , அமைச்சகம் ஆஃப் அறிவியல் , அண்டலூசின் மையம் ,

The structure of DNA is found to be actively involved in genome regulation


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The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later. The paper that has now been published by the team led by Felipe Cortés, head of the DNA Topology and Breaks Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with Silvia Jimeno González, professor at the University of Seville and head of the mRNA Transcription and Processing Group at the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), shows that this supercoiling characteristic of DNA s structure controls gene expression rather than being a mere collateral damage to be solved, as had been thought to date. The results are reported in the journa ....

Spain General , Silvia Jimeno Gonz , Felipe Cort , Andalusian Centre For Molecular Biology , University Of Seville , Health Institute , Spanish National Cancer Research Centre , Spanish Association Against Cancer , European Research Council , Processing Group , Ministry Of Science , Breaks Group , Andalusian Centre , Molecular Biology , Regenerative Medicine , Spanish Association Against , ஸ்பெயின் ஜநரல் , ஃபெலிப் கோர்ட் , பல்கலைக்கழகம் ஆஃப் செவில்லே , ஆரோக்கியம் நிறுவனம் , ஸ்பானிஷ் தேசிய புற்றுநோய் ஆராய்ச்சி மையம் , ஸ்பானிஷ் சங்கம் எதிராக புற்றுநோய் , ஐரோப்பிய ஆராய்ச்சி சபை , ப்ரோஸெஸிஂக் குழு , அமைச்சகம் ஆஃப் அறிவியல் , அண்டலூசின் மையம் ,

FMCSA: Beware of Companies Posing as Government


FMCSA: Beware of Companies Posing as Government Agencies
Traffic on I-380 south of Cedar Rapids, Iowa. (The Cedar Rapids Gazette)
Federal Motor Carrier Safety Administration officials posted a warning to truckers on April 8 to be aware of “predatory” companies that pose as government agencies.
The message came one day after the Iowa attorney general issued a news release announcing it reached an agreement with a Texas company that agreed to refund money to any Iowa truck drivers that paid it $149 to submit federal documents that can be filed for free.
The company, Compliance Processing Group of Frisco, Texas, sent past-due notices to Iowa truck drivers under the name FMCSA Compliance Processing Group. The letters warned that the truckers must “contact us immediately” or risk fines of $1,000 a day for a total of up to $10,000 and risk being taken out of service, “per the Federal Motor Carrier Safety Administration.” ....

United States , Tom Miller , Lynn Hicks , Robert Corrigan , Compliance Processing Group , Office Of Inspector , Motor Carrier Safety Administration , Compliance Processing Group Of Frisco , Federal Motor Carrier Safety Administration , Attorney General Tom Miller , Processing Group , Unified Carrier Registration , Inspector General Hotline , ஒன்றுபட்டது மாநிலங்களில் , டோம் மில்லர் , லின் ஹிக்ஸ் , ராபர்ட் கோரிகன் , அலுவலகம் ஆஃப் இன்ஸ்பெக்டர் , வழக்கறிஞர் ஜநரல் டோம் மில்லர் , ப்ரோஸெஸிஂக் குழு , ஒருங்கிணைந்த கேரியர் பதிவு , இன்ஸ்பெக்டர் ஜநரல் ஹாட்லைன் ,