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Robust T cell and humoral immune response to SARS-CoV-2 in patients with immunodeficiency

Robust T cell and humoral immune response to SARS-CoV-2 in patients with immunodeficiency
A study of immune-deficient adults and children has shown that patients who fail to respond positively to infections and vaccinations have robust humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) structural proteins.
Researchers Hannah Kinoshita
et al. described the clinical course, antibody, and T cell responses to SARS-CoV-2 structural proteins in a cohort of adult and pediatric patients with antibody deficiencies (related and unrelated) and infected with SARS-CoV-2. The researchers at Children s National Hospital are the first to demonstrate this response for immunocompromised patients. Their findings are published in the ....

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Immunocompromised pediatric patients showed T-cell activity and humoral immunity against SARS-CoV-2

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According to data from a cohort of adult and pediatric patients with antibody deficiencies, patients that often fail to make protective immune responses to infections and vaccinations showed robust T-cell activity and humoral immunity against SARS-CoV-2 structural proteins. The new study, led by researchers at Children s National Hospital, is the first to demonstrate a robust T-cell response against SARS-CoV-2 in immunocompromised patients.
If T-cell responses to SARS-CoV-2 are indeed protective, then it could suggest that adoptive T-cell immunotherapy might benefit more profoundly immunocompromised patients, said Michael Keller, M.D., director of the Translational Research Laboratory in the Program for Cell Enhancement and Technologies for Immunotherapy (CETI) at Children s National. Through our developing phase I T-cell immunotherapy protocol, we intend to investigate if coronavirus-specific T-cells may be protective following bone marrow transplantation, as ....

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Key Discoveries in Cancer Treatment to Be Presented During the Virtual 2020 AACC Annual Scientific Meeting

Key Discoveries in Cancer Treatment to Be Presented During the Virtual 2020 AACC Annual Scientific Meeting
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The Reach , United States , University Of Texas Southwestern Medical Center , Catherine Bollard , Christine Delong , Ralph Deberardinis , Brett Giroir , Molly Polen , White House Coronavirus Task , Drug Administration , Division Of Pediatric Genetics , Clinical Lab Expo , Children National Research Institute , Scientific Meeting Clinical Lab Expo , Program For Cell Enhancement , Scientific Meeting , Cell Therapies , Cancer Care , Cell Enhancement , National Research Institute , Pediatric Genetics , Texas Southwestern Medical Center , Human Cancer , Insights Into Mechanisms , New Therapies , Clinical Lab ,

Advances in COVID-19 Testing, Artificial Intelligence, Cancer Therapies, and The Future of Precision Medicine to Be Explored at The All-Virtual 2020 AACC Annual Scientific Meeting

Advances in COVID-19 Testing, Artificial Intelligence, Cancer Therapies, and The Future of Precision Medicine to Be Explored at The All-Virtual 2020 AACC Annual Scientific Meeting
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Key Discoveries in Cancer Treatment to Be Presented During the Virtual 2020 AACC Annual Scientific M

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13-Dec-2020
Key Discoveries in Cancer Treatment to Be Presented During the Virtual 2020 AACC Annual Scientific Meeting
CHICAGO, Dec. 13, 2020 /PRNewswire/ During the all-virtual 2020 AACC Annual Scientific Meeting & Clinical Lab Expo, leading scientific experts will dive into the groundbreaking advances that are the future of cancer care. One plenary session will focus on the cutting-edge treatment known as T cell therapy, while another will showcase recent discoveries about tumor metabolism that could lead to new, more effective cancer drugs.
Expanding the Reach of T Cell Therapy
T cell therapies train the immune system to target and destroy tumor cells, and have emerged in recent years as a promising alternative to chemotherapy and radiation. Immunotherapy has fewer side effects and has the potential to greatly increase patient survival rates, as T cells can live in the blood for years after a pat ....

The Reach , United States , University Of Texas Southwestern Medical Center , Catherine Bollard , Christine Delong , Ralph Deberardinis , Brett Giroir , Molly Polen , White House Coronavirus Task , Drug Administration , Division Of Pediatric Genetics , Clinical Lab Expo , Children National Research Institute , Scientific Meeting Clinical Lab Expo , Program For Cell Enhancement , Scientific Meeting , Cell Therapies , Cancer Care , Cell Enhancement , National Research Institute , Pediatric Genetics , Texas Southwestern Medical Center , Human Cancer , Insights Into Mechanisms , New Therapies , Clinical Lab ,