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100-Year-Old Vaccine Remains Broadly Protective in Newborns

Researchers at the Precision Vaccines Program at Boston Children’s Hospital recently partnered with the Expanded Program on Immunization Consortium, an international team studying early life immunization, to collect and comprehensively profile blood samples from newborns immunized with the century-old Bacille Calmette-Guérin (BCG) vaccine, using a powerful “big data” approach. ....

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Researchers reveal the mechanism of action of century-old BCG vaccine

The century-old Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the world's oldest and most widely used vaccines, used to immunize 100 million newborns every year. Given in countries with endemic TB, it has surprisingly been found to protect newborns and young infants against multiple bacterial and viral infections unrelated to TB. There's even some evidence that it can reduce severity of COVID-19. ....

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