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Promising candidate medication for preventing and reversing fentanyl-induced overdose

Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis. ....

United States , Kateryna Kon Shutterstock , Sprague Dawley , National Institute Of Health , National Institute On Drug Abuse , Drug Supply Program , Scripps Research Institute , Nature Communications , Illinois Institute Of Technology Research , Good Laboratory Practice , Institutional Animal Care , House Committees , Illinois Institute , Technology Research Institute , Mclean Hospital , Cayman Chemical , National Institute , Drug Abuse , Swiss Webster , Graphpad Prism , Animal Model , N Vitro , Monoclonal Antibody ,

Pharvaris Announces Positive Top-line Phase 2 Data from the CHAPTER-1 Study of Deucrictibant for the Prophylactic Treatment of HAE Attacks

Primary endpoint met: deucrictibant significantly reduced attack rate The primary endpoint of the CHAPTER-1 study measured the time-normalized number of investigator-confirmed HAE attacks during the treatment period. The monthly attack rate was reduced by 84.5% (p=0.0008) compared to placebo in participants who received 40 mg/day of deucrictibant. Primary endpoint met; 40 mg/day orally administered deucrictibant significantly reduced mean monthly attack rate by 84.5% (p=0.0008) compared to place ....

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Major UK study finds high demand and efficacy for HIV PrEP among sexual health service attendees

HIV PrEP requirement, duration, uptake, and usage among sexual health services (SHS) attendees in England. ....

City Of , United Kingdom , Marc Bruxelle Shutterstock , United Kingdom Health Security Agency , Genitourinary Medicine Clinic Activity Dataset , Sexual Health , Pre Exposure Prophylaxis ,

Novartis Recalls Sandimmune Oral Solution

Swiss drug major Novartis AG is recalling two lots of its Sandimmune Oral Solution (cyclosporine oral solution, USP), 100 mg/mL at the consumer level in the US, the U. ....

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Inhibitor Formation in Hemophilia A Prophylaxis

Robert Sidonio Jr, MD, MSc, discusses studies on inhibitor formation in patients with hemophilia A using prophylaxis, addressing the challenges of mitigating inhibitor risk and the impact on treatment strategies. ....

Robert Sidonio Jr , Jonathan Ogurchak , Hemophilia A , Inhibitor Formation , Treatment Strategies , Immunology Studies , Inhibitor Rate , Bleed Rates , Quality Of Life , Agenetic Mutation , Bethesda Units , Patient Outcomes , Genetic Factors ,