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The researcher team GUWAHATI: A team of Indo-US computational biologists, which has an Assam-born researcher Dr Swarup Roy, have found that one of the most easily accessible homeopathic medicine, Arsenicum Album 30, is a potential homoeopath drug for the global fight against Covid-19. The researchers said it has been one of the few studies to ascertain the efficacy of homeopathic medicines to treat Covid-19. The Union ministry of Ayush also advised for Arsenicum Album 30, which is derived from the chemical compound (mother tincture) of arsenic trioxide. The scientists' group led by Dr Swaru...

Medicine Follow U of T News U of T researchers receive more than $15 million for infrastructure to study brain inflammation, genetics Jennifer Gommerman and Charles Boone are leading two of four research projects at U of T that recently received support from the Canada Foundation for Innovation (photos by Nick Iwanyshyn and courtesy of Boone) The Canada Foundation for Innovation (CFI) has funded two major projects that will bring new research equipment to the University of Toronto’s Temerty Faculty of Medicine and its hospital partners, including a 7-Tesla MRI and imaging mass cytome...

XYS Activates the PI3K/Akt Pathway Network pharmacology suggested that the PI3k/Akt pathway was the main mechanism of action in IS treatment by XYS. Therefore, we evaluated the effect of XYS on the mRNA and protein expression of PI3k and Akt in PC12 cells. OGD/R inhibited mRNA expression of PI3K and Akt significantly in PC12 cells (Figures 9 and 10). Compared with the normal group, although protein expression of PI3K and Akt did not change significantly, phosphorylation of PI3K and Akt was inhibited significantly. Fortunately, XYS therapy could reverse this inhibition. These results indicated...

CDK1, BUB1) play important roles in the progression of G2/M phase in the cell cycle. 30,31 Furthermore, real-time PCR analysis was used to verify the results of transcriptome sequencing and the results indicated that the expression trends of the top 18 ranked degree genes were consistent with those obtained by RNA-seq, suggesting that the RNA-seq data reliably reflected the gene expression alterations (Figure 4B). According to the RNA-seq and real-time PCR results, the expressions of cell cycle regulated genes, such as CDK1, PLK1, and BUB1, were significantly decreased after sinomenine tr...

January issue of SLAS (Society for Laboratory Automation and Screening) Oak Brook, IL - The January edition of SLAS Discovery features the cover article, "Cryo-EM: The Resolution Revolution and Drug Discovery" by Taiana Maia de Oliveira, Ph.D., Lotte van Beek, Ph.D., Fiona Shilliday, Ph.D., Judit E. Debreczeni, Ph.D., and Chris Phillips, Ph.D., from AstraZeneca. Cryo-EM, a fast-growing technique in the pharmaceutical industry, enables structure determination of sought-after targets such as large multiprotein complexes and membrane proteins that eluded other structural bi...