DNA damage repair mechanisms activated in immune cells
We hypothesized that hospitalized Covid-19 patients would be characterized by increased levels of oxidative DNA damage & dysregulation of DNA repair machinery.
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We hypothesized that hospitalized Covid-19 patients would be characterized by increased levels of oxidative DNA damage & dysregulation of DNA repair machinery.
Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is turned into glucose in the small intestine, for which GLS is crucial. Animal studies suggest impaired IGN may have long-term effects on metabolic control and be associated with the development of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to thoroughly investigate IGN at the gene expression level in children with untreated celiac disease. Quanti...