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Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , South Korea , Dimethylacetamide Dmac , Nanozoomer Hamamatsu , Kaplan Meier , Ut Southwestern Medical Center , Q Zhong Ut Southwestern Medical Center , Yj Oh Yonsei University , Signalstain Antibody Diluent Cell Signaling Technology , Talazoparib Pfizer Inc , Signalstain Citrate Unmasking Solution Cell Signaling Technology , Ut Southwestern Medical Center Genomics Core , Biosplice Inc , A Kung Dana Farber Cancer Institute , Jackson Laboratory , Proteome Discoverer Software Thermo Fisher Scientific , Therapeutic Oncology Research , Hamon Center , Proteomexchange Consortium , D Baltimore California Institute Of Technology , Drug Administration , Cell Signaling Technology , Tandem Mass Tag , Gene Ontology , Cancer Dependency Map , Drug Sensitivity ,

Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway

Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Union Medical College Graduate Innovation Fund , Research Fund For Central Universities , National Key Rd Program Of China , Lipidall Technologies Co , Chinese Academy Of Medical Sciences Central Public , Novogene Co , American Association For The Advancement Of Science , National Natural Science Foundation Of China , Proteomexchange Consortium , Union Medical College , Chinese Academy Of Medical Sciences , Outstanding Young Scientist Program , Natural Science Foundation , Interest Scientific Institution Basal Research Fund , Qinglian Biotech Co , Institute Of Materia Medica , Innovation Fund For Medical Sciences , American Association , Science Journals Default , Beijing Qinglian Biotech , National Natural Science Foundation , Beijing Natural Science Foundation , National Key Rd Program , Special Research Fund , Central Universities ,

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair factors, Polθ function is activated in mitosis upon phosphorylation by Polo-like kinase 1 (PLK1). Phosphorylated Polθ is recruited by a direct interaction with the BRCA1 C-terminal domains of TOPBP1 to mitotic DSBs, where it mediates joining of broken DNA ends. Loss of Polθ leads to defective repair of mitotic DSBs, resulting in a loss of genome integrity. This is further exacerbated in ....

United States , Hela Gibco , Biotinylated Pol , Orbitrap Exploris , Lipofectamine Rnaimax Thermofisher , Jn Mark Glover , Mai Tai Deepsee , Giemsa Karyomax , Institut Curie , Jena Bioscience , Roper Zeiss , Ge Healthcare , Analysis Software , Proteomexchange Consortium , Magnetic Resonance Data Bank , C Terminal Flag P , Babe Blast , System Biosciences , Thermofisher Scientific , Santa Cruz Biotechnology , Cell Signaling , Novus Biologicals , Bethyl Laboratories , Spectra Physics , Mai Tai Laser , Omplete Protease Inhibitor Cocktail ,

Fibroblasts generate topographical cues that steer cancer cell migration

Fibroblasts generate topographical cues that steer cancer cell migration
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Poitou Charentes , France General , Le Pont , Provence Alpes Côd Azur , United States , Cafs Caax Morange , Insitut Curie , Gustave Roussy , Abbelight Cachan , Rnaimax Invitrogen , Fibronectin Corning , Vale Addgene , Institut Curie , Fondation Tourre , Proteomexchange Consortium , European Union Horizon , Institut National Du Cancer , Santa Cruz Biotechnology Inc , Beug Foundation , Gustave Roussy Institute , Cell Signaling Technology , University Of California , Mattek Corporation , Leica Microsystems Ltd , Matic Vignjevic , Knock Out ,

MyJournals.org - Science - 'IJMS, Vol. 24, Pages 12592: Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma' (International Journal of Molecular Sciences)

MyJournals.org - Science - 'IJMS, Vol. 24, Pages 12592: Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma' (International Journal of Molecular Sciences)
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