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/PRNewswire/ -- The "Protein Expression Market - A Global and Regional Analysis: Focus on Application, End User, Product, Expression System, and Region -...
Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport oxygen over a long range, its physiological roles outside erythrocytes are largely elusive1,2. Here we found that chondrocytes produced massive amounts of haemoglobin to form eosin-positive bodies in their cytoplasm. The haemoglobin body (Hedy) is a membraneless condensate characterized by phase separation. Production of haemoglobin in chondrocytes is controlled by hypoxia and is dependent on KLF1 rather than the HIF1/2α pathway. Deletion of haemoglobin in chondrocytes leads to Hedy loss along wi...
DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ) repairs mitotic DSBs and thereby maintains genome integrity. In contrast to other DSB repair facto...
Dublin, Aug. 30, 2023 (GLOBE NEWSWIRE) -- The "Conjugation and Labeling Services Market Trends and Global Forecasts, 2023-2035" report has been added to ...
/PRNewswire/ -- The "Conjugation and Labeling Services Market: Distribution by Type of Molecule, Type of Molecular Conjugate / Label, and Key Geographical...