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Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Buenos Aires , Distrito Federal , Pkas Mohanty , Eleni Polatoglou , Trypanosoma Bachmaier , Thomas Carell , Ricardo Biondi , Pkas Canaves , Michaela Smolle , Jena Bioscience , Ligprep Schr , Ralph Heermann , Pkacs Jena Bioscience , Interchim Uptisphere , Transfected Mitat , Life Sciences Munich , Gene Center , Ge Healthcare , Gibbs Free Energy , Omicron Biochemicals Inc , Bb Hydrogen , Protein Data Bank , Structure Activity Relationship , Supplementary Table , Supplementary Movie , Andreas Anger ,

Molecular science VR startup Nanome launches AI copilot MARA

MARA will be integrated into Nanome's XR platform to save chemists' time and open new abilities for SAR analysis. ....

Steve Mccloskey , Keita Funakawa , Diego Based Nanome , Structure Activity Relationship ,

"Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the" by Yuan Ma, Qiushi Cao et al.

Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in the human (h) α3β4 nicotinic acetylcholine receptors (nAChRs). In this study, the binding mode of Czon1107 to hα3β4 nAChR was investigated using molecular dynamics simulations coupled with mutagenesis studies of the peptide and electrophysiology studies on heterologous hα3β4 nAChRs. Overall, this study clarifies the structure-activity relationship of Czon1107 and hα3β4 nAChR and provides an important experimental and theoretical basis for the development of new peptide drugs. ....

Ach Evoked Currents , Allosteric Inhibitor , Molecular Dynamics Simulations , Structure Activity Relationship ,

Eleven Therapeutics Announces $22 Million in Seed Funding

/PRNewswire/ Eleven Therapeutics, a biotechnology company leading the AI revolution in nucleic acid therapeutics, announced today that it has raised a total. ....

United States , United Kingdom , Tel Aviv , Greg Hannon , Daniel Douek , Yaniv Erlich , Iris Grossman , Vaccine Research Center , Development Agreement , Cancer Research United Kingdom Cambridge Institute , National Institute Of Allergy , National Institutes Of Health , Melinda Gates Foundation , University Of Cambridge , Vaccine Research Centre , Research Collaborative , Harel Technology Investments , Gates Foundation , Structure Activity Relationship , Cooperative Research , Eleven Therapeutics , Human Immunology Section , National Institute , Infectious Disease , National Institutes , Kindred Capital ,

Big Pharma shares substance data to decrease animal testing

Four companies have shared unpublished hazard data for drug substances to enhance database-dependent computational tools and help reduce animal testing. ....

Ofelia Bercaru , Jan Backman , Roche Ltd , Merck Kga , European Chemical Agency , Merck Kgaa , European Federation Of Pharmaceutical Industries , Boehringer Ingelheim , Big Pharma , European Federation , Pharmaceutical Industries , Structure Activity Relationship , Chemical Legislation ,