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The genome of the SARS-CoV-2 virus encodes 29 proteins, one of which is an ion channel called E. This channel, which transports protons and calcium ions, induces infected cells to launch an inflammatory response that damages tissues and contributes to the symptoms of Covid-19.
MIT chemists discovered the structure of the “open” state of the coronavirus E channel, which contributes to the inflammation seen in cells of Covid-19 patients. The structure could guide researchers in developing antiviral drugs that block the channel and help prevent inflammation.
Boston MA (SPX) Jul 14, 2023 - Many neurodegenerative diseases, including Alzheimer's, are characterized by tangled proteins called Tau fibrils. In a new study, MIT chemists have gained insight into how these fibrils form, and id
MIT chemists have gained insight into how Tau tangles form in the brains of people with Alzheimer’s disease. They also identified a potential target for drugs that could interfere with tangle formation.
One of the hallmarks of Alzheimer’s disease is the presence of neurofibrillary tangles in the brain. These tangles, made of tau proteins, impair neurons’ ability to function normally and can cause the cells to die.A new study from MIT chemists has re