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Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing (PANDORA) is a new RNA sequencing method developed by scientists from the University of California, Riverside (UCR). Unlike Pandora’s box which refers to a source of endless complications or trouble arising from a single, simple miscalculation—this Pandora, may be a source of opportunity as it can help discover numerous modified small RNAs that were previously undetectable. The researchers have published their method and findings in the journal  “Although high-throughput RNA sequencing (RNA-seq) has greatly advance...

Cells are full of RNA -- intermediate molecules used to synthesize proteins from DNA -- in complex and diverse forms, such as ribosomal RNA (rRNA) and transfer RNA (tRNA). Small noncoding RNAs, including micro RNA (miRNA) and tRNA-derived small RNA (tsRNA), are known to contribute to many conditions, such as cancer and neurological diseases. These small RNAs contain many RNA modifications. Known to be abundant in mammalian somatic cells, miRNA control the kinds and amounts of proteins the cells make. They are by far the most-studied class of small RNA molecules. The use of high-throughput RNA...