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Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences


Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences
In a recent
bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis. At the same time, a unique strain with an emerging mutation in an altered spike glycoprotein may be present in Hawaii.
Over the past year, there was a notable evolution of SARS-CoV-2 around the globe, which will continue to pose a serious threat. As of January 2021, four novel viral variants have been reported from the United Kingdom (VOC 202012/01/B.1.1.7), South Africa (501Y.V2), Nigeria (B.1.207), and Denmark (Mink Cluster V). ....

United Kingdom , South Africa , United States , Davidp Maison , University Of Hawaii , Genetic Characteristics , Hawaii Reveals , Image Credit , Medicine Biocontainment Facility , Maximum Likelihood , Gene Region , Study Along , Annotated Primers , Cysteine Residues , Receptor Binding Domain Figure , Insightful Science , New York , Native Hawaiians , Pacific Islanders , Sars Cov 2 , Corona Virus , Coronavirus Disease Covid 19 , Sanger Sequencing , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , ஒன்றுபட்டது கிஂக்டம் ,

Scientists gain new insight into how the immune system can be better used to destroy cancer cells


Scientists gain new insight into how the immune system can be better used to destroy cancer cells
Scientists at the University of Southampton s Centre for Cancer Immunology have gained new insight into how the immune system can be better used to find and kill cancer cells.
Working with BioInvent International, a team led by Professor Mark Cragg and Dr Jane Willoughby from the Antibody and Vaccine Group, based at the Centre, have shown that antibodies, designed to target the molecule OX40, give a more active immune response when they bind closer to the cell membrane and can be modified to attack cancer in different ways. ....

Jane Willoughby , Mark Cragg , Emily Henderson , University Of Southampton , Bioinvent International , Vaccine Group , University Of Southampton Centre For Cancer Immunology , Cancer Immunology , Professor Mark Cragg , Cell Membrane , Immune Response , Immune System , T Cell , ஜேன் விருப்பம் , குறி க்ர்யாக் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் , தடுப்பூசி குழு , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் மையம் க்கு புற்றுநோய் நோயெதிர்ப்பு , புற்றுநோய் நோயெதிர்ப்பு , ப்ரொஃபெஸர் குறி க்ர்யாக் , செல் சவ்வு , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு , நோயெதிர்ப்பு சிகிச்சை , டி செல் ,

New approach to tame botulinum toxin for drug delivery


New approach to tame botulinum toxin for drug delivery
While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins produced by Clostridium botulinum the most potent toxins known. These toxins are often found in contaminated food (home canning being a major culprit). Infants can also develop botulism from ingesting C. botulinum spores in honey, soil, or dust; the bacterium then colonizes their intestines and produces the toxin.
Once paralysis develops, there is no way to reverse it, other than waiting for the toxins to wear off. People with serious cases of botulism may need to be maintained on ventilators for weeks or months. But a new treatment approach and delivery vehicle, described today in ....

Tufts University , United States , Shin Ichiro Miyashita , Emily Henderson , Boston Children Hospital Department Of Urology , Science Translational Medicine , Boston Children , Corresponding Author , Charles Shoemaker , Clostridium Botulinum , Drug Delivery , Motor Neurons , டஃப்ட்ஸ் பல்கலைக்கழகம் , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , போஸ்டன் குழந்தைகள் மருத்துவமனை துறை ஆஃப் சிறுநீரகம் , அறிவியல் மொழிபெயர்ப்பு மருந்து , போஸ்டன் குழந்தைகள் , சார்லஸ் ஷூ தயாரிப்பாளர் , மருந்து டெலிவரி ,