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The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor1–3 (BDNF), and also through electrophysiologically functional neuron-to-glioma synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors4,5. The consequent glioma cell membrane depolarization drives tumour proliferation4,6. In the healthy brain, activity-regulated secretion of BDNF promotes adaptive plasticity of ...

During the Sheridan County Republican Party Central Committee Meeting last Saturday, the committee voted to censure State Representative Cyrus Western (R-HD51). According to the Resolution, Western “falsely swore an oath of office in January of 2023 declaring that he was not under legal investiga

State Representative Cyrus Western, after the Wyoming Legislature wrapped up their 2023 session last week, spoke with Sheridan Media about his thoughts on the session. In an earlier interview he talked specifically about the Capital Construction Bill, Senate File 146, and how important it was to

Inhibition of Dectin-1 Alleviates Neuroinflammatory Injury by Attenuating NLRP3 Inflammasome-Mediated Pyroptosis After Intracerebral Hemorrhage in Mice: Preliminary Study Results

Disintegrin and metalloproteinase 9 (ADAM9) is involved in the pathogenesis of cigarette smoke (CS)-associated COPD. Click to read more...