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Abstract Background: Understanding changes in infectiousness during SARS-COV-2 infections is critical to assess the effectiveness of public health measures such as contact tracing. Methods: Here, we develop a novel mechanistic approach to infer the infectiousness profile of SARS-COV-2 infected individuals using data from known infector-infectee pairs. We compare estimates of key epidemiological quantities generated using our mechanistic method with analogous estimates generated using previous approaches. Results: The mechanistic method provides an improved fit to data from SARS-CoV-2 infector...

 E-Mail Strenuous efforts to prevent and treat malaria in recent decades have brought great benefits, particularly against disease caused by Plasmodium falciparum in countries in Africa and the Americas. But malaria caused by its "stealthier and more resilient cousin", P. vivax, now needs to be confronted with high priority, say Lorenz von Seidlein and Nicholas White of the Mahidol Oxford Tropical Medicine Research Unit in Bangkok, Thailand in a Perspective. The piece introduces a Collection on the prevention and treatment of P. vivax malaria in the open access journal PLOS Medicine, publ...

Hanage and Russell conjecture [see also ( 1)] that intermediate levels of immunity may sufficiently restrict within-host viral population size and thus limit adaptive mutations. The evolutionary model in our Research Article encompasses a wide range of scenarios, including the optimistic one Hanage and Russell propose (see scenario 1 in Fig. 4A of the Research Article). However, we also argued that uncertainties in immunodynamics, and in particular evolutionary dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dominate our ability to project key scenarios. We therefore...

PHOTO: RICARDO ARDUENGO/AFP/GETTY IMAGES In their Research Article, “Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes” (this issue, p. 363; published online 9 March), C. M. Saad-Roy et al. write that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine dosing regimens generating intermediate levels of immunity could accelerate the emergence of new variants that are capable of wholly or partially escaping immunity induced by prior infection or vaccination—immune-escape variants. Their argument assumes that such variants are most likely...

Justin Garwood (Photo provided) SARANAC LAKE — Justin D. Garwood, who grew up in Saranac Lake and moved back with his family last year, recently saw the publication of a book he wrote about classroom management. “Reclaim Your Challenging Classroom” is intended to guide new and veteran teachers in developing effective classroom management techniques, with a particular focus on students with emotional or behavioral disorders and those experiencing trauma. This guide empowers teachers to create a positive and engaging learning environment that is grounded in the student-teacher relation...