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Curcumin-Fenugreek complex may pass blood-brain barrier, impact brain waves A curcumin-fenugreek complex (CurQfen) may impact brain waves and boost audio-reaction time compared to placebo and unformulated curcumin, says a new study. Writing in Nutritional Neuroscience, scientists from Aman Hospital and Research Centre (India), Akay Natural Ingredients (India), Mahatma Gandhi University (India), and Life Extension, Inc. (USA) report that the changes observed for brain waves are “consistent with penetration of the blood-brain-barrier”. “We were surprised to see the results of the 30-day clinical trial when the software-assisted analysis of the Electroencephalogram (EEG) data was completed, since this is the very first time the effect of curcumin on brain waves was investigated as a proof of its Blood-Brain-Barrier (BBB)-permeability and brain bioavailability,” said the researchers in a press release from Akay Natural Ingredients, which funded the study.