New treatments for Alzheimer's disease
Blazing trails or the road to nowhere? Donanemab is a new monoclonal antibody treatment that binds to amyloid β to stimulate microglial removal of amyloid plaques from the brain in people with Alzheimer’s disease.1 In the recently published Trailblazer-ALZ 2 trial in 1736 adults with early symptomatic disease, participants treated with donanemab had a mean decline over 18 months that was 3.03 points less than those given placebo on a 144 point scale of cognition and functional ability (integrated Alzheimer disease rating scale (−6.02 v −9.27; difference 3.25, 95% confidence interval 1.8...
Source: bmj.com
