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Flare Therapeutics, a Cambridge, Mass. – based biotechnology company targeting transcription factors to discover precision medicines for cancer and other diseases, raised $82m in Series A financing. The round was led by Third Rock Ventures with participation from Boxer Capital, Nextech Invest, Casdin Capital, Invus Financial Advisors and Eventide Asset Management. The company intends to use the funds for further advancement of its lead program in precision oncology toward the clinic proprietary assays to discover small molecules that target transcription factors at switch sites.    Led ...

Published May 13, 2021 Dollar Photo Club The instructions for making a human are long and complicated. They involve over 3 billion sets of microscopic letters, so tightly coiled that, if unwound, they would be taller than the average person. The daunting task of reading these instructions involves a type of protein called transcription factors. But, while integral to life, these proteins can also cause disease when they mutate or malfunction. For drug developers, transcription factors are an attractive target. "Every biotech company that...

It may not really be the weather for it today but we are again able to visit a pub to have a drink outdoors after the latest easing of lockdown restrictions. The prospect of being able to go out and enjoy a drink and a socially distanced conversation may be another step towards getting back to a semblance of normality, but it also serves as another reminder of the pubs that are no longer with us. We asked members of our nostalgia Facebook group ‘We grew up in Watford’ which former pub in the area they would have visited first this week and why.

Former undisputed world middleweight champion ‘Marvelous’ Marvin Hagler has died at the age of 66, his wife announced on Saturday. Hagler had ruled the division from 1979, but was dethroned following a controversial defeat by Sugar Ray Leonard in April 1987. Marvelous Marvin Hagler. The bloke you show to the aliens when they ask what the word ‘boxer’ means. What a massive loss. pic.twitter.com/UurYBksqQd— Matt Christie (@MattCBoxingNews) March 14, 2021 Kay Hagler wrote on the official Marvelous Marvin Hagler Fan Club Facebook page: “I am sorry to make a very sad announce...

Updated: March 14, 2021, 10:57 am Marvin Hagler (centre) ruled the middleweight division for much of the 1980s (Nick Potts/PA) Sign up for our daily newsletter featuring the top stories from The Press and Journal. Thank you for signing up to The Press and Journal newsletter. Something went wrong - please try again later. Sign Up Marvelous Marvin Hagler ruled over the middleweight division with an iron fist for much of the 1980s before his reign was ended by Sugar Ray Leonard in one of the most controversial judging decisions of all time. Hagler, who has died suddenly aged 66, made 12 s...